The adaptive potential of skeletal muscle fibers.
The adaptive potential of skeletal muscle fibers.
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DOI：
10.1139/h02-023
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发表时间：
2002-08-01
期刊：
影响因子：
--
通讯作者：
Pette, D
中科院分区：
文献类型：
--
作者：
Pette, D
哺乳动物骨骼肌纤维显示出很大的适应潜力。这种潜力源于肌肉纤维能够调整其分子、功能和代谢特性，以响应改变的功能需求，如神经肌肉活动或机械负荷的变化。肌原纤维和其他蛋白质亚型表达的适应性变化会导致纤维类型的转变。这些转变按顺序发生，包括纯纤维和混杂纤维的光谱。根据功能需求改变的性质、强度和持续时间的不同，肌肉纤维可能会经历慢或快方向的功能转变，以及有氧-氧化或糖酵解方向的代谢转变。两个方向上的最大可能跃迁范围取决于纤维表型，并由其在纤维光谱中的初始位置决定。
Mammalian skeletal muscle fibers display a great adaptive potential. This potential results from the ability of muscle fibers to adjust their molecular, functional, and metabolic properties in response to altered functional demands, such as changes in neuromuscular activity or mechanical loading. Adaptive changes in the expression of myofibrillar and other, protein isoforms result in fiber type transitions. These transitions occur in a sequential order and encompass a spectrum of pure and hybrid fibers. Depending on the quality, intensity, and duration of the alterations in functional demand, muscle fibers may undergo functional transitions in the direction of slow or fast, as well as metabolic transitions in the direction of aerobic-oxidative or glycolytic. The maximum range of possible transitions in either direction depends on the fiber phenotype and is determined by its initial location in the fiber spectrum.