Unusual Boronium Salt Shows Antifungal Activity Comparable to a Commercial Quaternary Ammonium Disinfectant
Unusual Boronium Salt Shows Antifungal Activity Comparable to a Commercial Quaternary Ammonium Disinfectant
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不寻常的硼盐显示出与商业季铵消毒剂相当的抗真菌活性
DOI：
10.1002/slct.202104344
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发表时间：
2022
期刊：
影响因子：
2.1
通讯作者：
Wierzbicki, Andrzej
中科院分区：
文献类型：
--
作者：
Ravine, Terrence J.;Soltani, Mohammad;Davis, Jr., James H.;Salter, Edward A.;Wierzbicki, Andrzej
以前，有报道称，一种含有末端苄基的硼铵盐对大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌的抗菌活性比商业季铵消毒剂溶液更强。目前的研究结果表明，与相同的四种消毒剂相比，不含苄基的相同硼铵盐对活跃生长的白色念珠菌、酵母菌和烟曲霉具有相同或更好的抗真菌活性。该化合物还显示出对休眠菌的抗真菌活性。烟曲霉孢子可与quat消毒剂相媲美。相比之下，在所有3种真菌测试条件下，带有苯基的硼离子的效果比非苯基化形式或四氯消毒剂低4 - 16倍。没有苯基的硼盐在本研究中表现出显著的抗真菌活性，而在以前的研究中没有表现出任何抗菌活性，这一观察结果特别令人感兴趣。这一发现代表了先前细菌测试的翻转结果。这表明末端苄基的存在极大地影响了硼离子与真菌膜相互作用的能力。
Previously, a boronium salt possessing a terminal benzyl group was reported to have greater antibacterial activity than a commercial quaternary ammonium disinfectant solution againstEscherichia coli,Pseudomonas aeruginosa, andStaphylococcus aureus. Results of the current study indicate that the same boronium salt without a benzyl group, exhibited equal or better antifungal activity against actively growingCandida albicansyeast andAspergillus fumigatusmold when compared to the same quat disinfectant. This same compound also displayed antifungal activity against dormantA. fumigatusspores comparable to the quat disinfectant. In contrast, the boronium ion with a benzyl group was 4–16X less effective than either the non‐benzylated form or quat disinfectant for all 3 fungal test conditions. The observation that the boronium salt without a benzyl group exhibited substantial antifungal activity in the current study but did not display any antibacterial activity in the previous study is of particular interest. This finding represents a flip‐flop outcome from the previous bacterial testing. It suggests that the presence of a terminal benzyl group greatly influences the boronium ion's ability to interact with fungal membranes.
与商业季铵消毒剂相比，新型硼盐表现出显着的抗菌活性。
影响因子：
2.7
作者：
M. Soltani;Terrence J. Ravine;James H. Davis
通讯作者：
James H. Davis