Optic Disc Damage Staging System
Optic Disc Damage Staging System
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DOI：
10.1097/ijg.0b013e3181ca7303
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发表时间：
2010-09-01
影响因子：
2
通讯作者：
Salvetat, Maria Letizia
中科院分区：
文献类型：
--
作者：
Brusini, Paolo;Zeppieri, Marco;Salvetat, Maria Letizia
目的：评价视盘损伤分期系统(ODDSS)：一种新的基于视盘大小、神经环丢失程度和定位的视盘(OD)临床分类方法。对方法的准确性、重复性和可靠性进行了研究。方法：在这项前瞻性横断面研究中，68例开角型青光眼(POAG)患者和40例对照组的1只眼接受了标准自动视野检查(SAP)、HRT-II和OD检查。根据ODDSS和HRT参数确定区分正常眼和POAG眼的敏感度、特异度和受试者工作特征曲线下面积(AROC)。结果：ODDSS的敏感性为72.0%~89.7%，特异性为92.5%~100%。ODDSS的Arocs(0.89比0.94)和表现最好的HRT参数(垂直杯/盘比率0.88)之间的差异没有统计学意义。ODDSS观察员间一致性介于0.33至0.78之间；观察员间一致性介于0.53至0.89之间。与HRT-MRA的符合率为0.50~0.87。结论：ODDSS是一种评估、记录和共享临床OD表现信息的新方法。我们的初步结果表明，它在青光眼检测中提供了良好的敏感性和特异性。观察员间和观察员内的协议从一般到良好不等。
Purpose: To evaluate the optic disc damage staging system (ODDSS); a new clinical method of optic disc (OD) classification based on OD size, neural rim (NR) loss severity and localization. Accuracy, reproducibility, and reliability were studied. Agreement of ODDSS with the Heidelberg-Retina-Tomograph (HRT) results was evaluated.Methods: One eye of 68 consecutive open-angle glaucoma (POAG) patients and 40 controls underwent standard automated perimetry (SAP), HRT-II, and OD examination using the ODDSS classification by 3 independent graders in this prospective cross-sectional study. Sensitivity, specificity, and area under the receiver operating characteristic curve (AROC) in discriminating between normal and POAG eyes were determined for ODDSS and HRT parameters. ODDSS intraobserver and interobserver agreement and agreement with HRT-Moorfield-Regression-Analysis (MRA) were assessed.Results: ODDSS sensitivity ranged from 72.0% to 89.7%; specificity ranged from 92.5% to 100%. Differences between AROCs for ODDSS (0.89 to 0.94) and for the best-performing HRT parameter (Vertical Cup/Disc Ratio 0.88) were not statistically significant. ODDSS interobserver agreement ranged from 0.33 to 0.78; intraobserver agreement ranged from 0.53 to 0.89. Agreement with HRT-MRA ranged from 0.50 to 0.87.Conclusions: ODDSS is a new method for assessing, recording, and sharing information about the clinical OD appearance. Our preliminary results show that it provides good sensitivity and specificity in glaucoma detection. The interobserver and intraobserver agreement ranged from fair to good.