Postmenopausal Women With Osteopenia Have Higher Cortical Porosity and Thinner Cortices at the Distal Radius and Tibia Than Women With Normal aBMD: An In Vivo HR-pQCT Study
Postmenopausal Women With Osteopenia Have Higher Cortical Porosity and Thinner Cortices at the Distal Radius and Tibia Than Women With Normal aBMD: An In Vivo HR-pQCT Study
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DOI：
10.1359/jbmr.091020
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发表时间：
2010-04-01
影响因子：
6.2
通讯作者：
Boyd, Steven K.
中科院分区：
文献类型：
--
作者：
Nishiyama, Kyle K.;Macdonald, Heather M.;Boyd, Steven K.
皮质孔隙度增加本研究的目的是验证用于高分辨率外周定量计算机断层扫描（HR-pQCT）的自动分割方法，以测量Ct Po和Ct Th，并使用它来比较具有正常、骨质减少、和骨质疏松性区域骨矿物质密度（aBMD）使用尸体前臂（n = 10）和微计算机断层扫描（μ CT）作为金标准来验证Ct、Po和Ct Th测量。该分析应用于来自加拿大多中心骨质疏松研究（n = 280，18 - 90岁）的阿尔伯塔省卡尔加里队列的参与者子集的桡骨远端和胫骨HR-pQCT扫描。63例正常绝经前妇女Ct Po和Ct Th结果的协方差分析（双能X线骨密度法股骨颈T-评分> -1）、87名正常绝经后、121名骨质疏松绝经后和9名绝经后骨质疏松妇女，使用线性回归分析和Bland-Altman图评估HR-pQCT和mu CT测量值之间的一致性，导致Ct Po和Ct Th的r（2）值分别为0.80和0.98。在两个部位，绝经后Ct Po均高于绝经后，（所有组）比绝经前妇女（3 2%~ 12 9%，p <0 0 1）正常绝经前后妇女各部位Ct、Th无显著性差异;然而，骨质减少和骨质疏松妇女都有较薄的（-12.8%至-30.3%，p <0.01），多孔性更强（2.1%至8.1%，p < 001）我们的方法提供了一个有价值的工具，测量Ct Po和Ct Th在体内，并调查之间的关联，皮质骨结构、年龄和疾病状态。2010年美国骨与矿物质研究学会
Increases in cortical porosity (Ct.Po) and decreases in cortical thickness (Ct Th) are associated with increased bone fragility The purpose of this study was to validate an autosegmentation method for high-resolution peripheral quantitative computed tomography (HR-pQCT) scans to measure Ct Po and Ct Th and use it to compare Ct.Po and Ct.Th between pre- and postmenopausal women with normal, osteopenic, and osteoporotic areal bone mineral density (aBMD) The Ct.Po and Ct Th measurements were validated using cadaver forearms (n = 10) and micro-computed tomography (mu CT) as the gold standard. The analysis was applied to distal radius and tibia HR-pQCT scans from a subset of participants from the Calgary, Alberta, cohort of the Canadian Multicentre Osteoporosis Study (n = 280, 18 to 90 years). Analysis of covariance compared Ct Po and Ct Th outcomes between 63 normal premenopausal (dual-energy X-ray absorptiometry femoral neck T-score > -1), 87 normal postmenopausal, 121 osteopenic postmenopausal, and 9 osteoporotic postmenopausal women Linear regression analysis and Bland-Altman plots were used to assess the agreement between the HR-pQCT and mu CT measurements, resulting in r(2) values of 080 for Ct Po and 0.98 for Ct Th At both sites, Ct Po was higher in postmenopausal (all groups) than in premenopausal women (3 2% to 12 9%, p < 001) Ct.Th was not significantly different between normal premenopausal and postmenopausal women at either site; however, both osteopenic and osteoporotic women had thinner (-12.8% to -30 3%, p < 01), more porous (2.1% to 8.1%, p < 001) cortices than normal postmenopausal women Our method offers promise as a valuable tool to measure Ct Po and Ct Th in vivo and investigate associations among cortical bone structure, age, and disease status. C) 2010 American Society for Bone and Mineral Research