Durable coexistence of donor and recipient strains after fecal microbiota transplantation
Durable coexistence of donor and recipient strains after fecal microbiota transplantation
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DOI：
10.1126/science.aad8852
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发表时间：
2016-04-29
期刊：
影响因子：
56.9
通讯作者：
Bork, Peer
中科院分区：
文献类型：
--
作者：
Li, Simone S.;Zhu, Ana;Bork, Peer
粪便微生物群移植（FMT）在治疗复发性艰难梭菌感染方面已显示出疗效，并越来越多地应用于其他胃肠道疾病，但原生和引入的微生物菌株的命运仍在很大程度上未知。为了量化供体微生物群定植的程度，我们使用宏基因组中的单核苷酸变异监测了最近一项代谢综合征患者粪便样本中的菌株种群。我们发现供体和受体菌株广泛共存，持续治疗后3个月。同种菌株的定植成功率高于新物种，后者落在健康个体在类似时间框架内观察到的波动水平内。此外，同一供体受体表现出不同程度的微生物群转移，表明微生物组耐药性和供体-受体相容性的个体模式。
Fecal microbiota transplantation (FMT) has shown efficacy in treating recurrent Clostridium difficile infection and is increasingly being applied to other gastrointestinal disorders, yet the fate of native and introduced microbial strains remains largely unknown. To quantify the extent of donor microbiota colonization, we monitored strain populations in fecal samples from a recent FMT study on metabolic syndrome patients using single-nucleotide variants in metagenomes. We found extensive coexistence of donor and recipient strains, persisting 3 months after treatment. Colonization success was greater for conspecific strains than for new species, the latter falling within fluctuation levels observed in healthy individuals over a similar time frame. Furthermore, same-donor recipients displayed varying degrees of microbiota transfer, indicating individual patterns of microbiome resistance and donor-recipient compatibilities.