1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4.
1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4.
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DOI：
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发表时间：
1998-06
影响因子：
4.4
通讯作者：
M. Cantorna;W. D. Woodward;C. Hayes;H. DeLuca
中科院分区：
文献类型：
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作者：
M. Cantorna;W. D. Woodward;C. Hayes;H. DeLuca
之前我们证明 1,25-二羟基维生素 D3 可以阻止复发性脑脊髓炎的进展。我们现在提出，1,25-二羟基维生素 D3 通过刺激抑制脑炎过程的细胞的分化和/或功能来阻止这些自身免疫症状。为了支持这一观点，我们发现给小鼠施用 1,25-二羟基维生素 D3 可使 IL-4 转录物增加 3 至 25 倍，TGF-β 1 转录物增加 4 至 24 倍。同样，与对照组相比，1,25-二羟基维生素 D3 治疗小鼠的中枢神经系统中 IL-4 和 TGF-β 1 转录物更高。 1,25-二羟基维生素 D3 治疗小鼠淋巴结中可回收的细胞数量仅为对照组的 50%。总体而言，1,25-二羟基维生素 D3 治疗导致淋巴细胞总数净损失，同时 IL-4 和 TGF-β 1 转录物的数量增加。 1,25-二羟基维生素 D3 导致这两种抗炎细胞因子的全身和局部表达增加，可能是该药物具有阻断脑脊髓炎能力的原因。
Previously we demonstrated that 1,25-dihydroxyvitamin D3 blocks the progression of relapsing encephalomyelitis. We now propose that 1,25-dihydroxyvitamin D3 blocks these autoimmune symptoms by stimulating the differentiation and/or function of cells that inhibit the encephalitogenic process. To support this belief, we have found that 1,25-dihydroxyvitamin D3 administration to mice increases IL-4 transcripts by 3- to 25-fold and TGF-beta 1 transcripts by 4- to 24-fold. Similarly, IL-4 and TGF-beta 1 transcripts were higher in the central nervous system of 1,25-dihydroxyvitamin D3-treated mice compared with controls. The number of cells recoverable from the lymph nodes of 1,25-dihydroxyvitamin D3-treated mice was only 50% that of controls. Overall, 1,25-dihydroxyvitamin D3 treatment causes a net loss in the total number of lymphocytes while the number of IL-4 and TGF-beta 1 transcripts increased. The systemic and local increase in the expression of these two anti-inflammatory cytokines by 1,25-dihydroxyvitamin D3 may be responsible for the ability of this drug to block encephalomyelitis.