Effects of naltrexone pellet implantation on morphine tolerance and physical dependence in the rat.
Effects of naltrexone pellet implantation on morphine tolerance and physical dependence in the rat.
复制标题
纳曲酮颗粒植入对大鼠吗啡耐受和身体依赖性的影响。
DOI：
10.1016/0306-3623(94)90025-6
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Thorat,SN
中科院分区：
文献类型：
--
作者：
Bhargava,HN;Matwyshyn,GA;Gerk,PM;Bozek,PS;Bailey,MD;Ko,KH;Simko,RJ;Thorat,SN
1.在雄性Sprague-Dawley大鼠中评估了含有10或30 mg纳洛酮碱的纳洛酮丸剂对吗啡耐受性和身体依赖性发展的影响。通过皮下植入6个吗啡丸，每个丸含有75 mg吗啡碱，持续7天诱导对吗啡的耐受依赖。2.纳洛酮颗粒植入阻断了对吗啡镇痛和热效应的耐受性的发展。同样，纳洛酮颗粒植入逆转吗啡戒断诱导的体重减轻。含10和30 mg纳洛酮的丸剂的效果没有差异。3.研究了纳洛酮（10 mg）颗粒植入对纳洛酮促戒断的各种体征（如体重减轻、体温过低以及尿和粪便排出量增加）的影响。纳洛酮颗粒植入未改变纳洛酮催促戒断诱导的体重减轻。同时植入纳曲酮颗粒可阻止吗啡依赖大鼠中纳曲酮催促戒断引起的体温过低、粪便和尿液排出量增加。4.这些结果表明，单粒10毫克纳曲酮可以有效阻断大鼠的吗啡耐受性和身体依赖性。这样的程序可能是有用的，在阿片类药物成瘾过程中所涉及的生化，内分泌和免疫机制的研究。
1. The effect of naltrexone pellets containing either 10 or 30 mg of naltrexone base on the development of tolerance and physical dependence on morphine was assessed in male Sprague-Dawley rats. Tolerance-dependence on morphine was induced by sc implantation of six morphine pellets, each containing 75 mg morphine base for 7 days. 2. Naltrexone pellet implantation blocked the development of tolerance to the analgesic and hyperthermic effects of morphine. Similarly, naltrexone pellet implantation reversed morphine withdrawal-induced body weight loss. The effect of pellets containing 10 and 30 mg naltrexone did not differ. 3. The effect of naltrexone (10 mg) pellet implantation on various signs of naltrexone-precipitated withdrawal such as body weight loss, hypothermia and increases in urinary and fecal output was investigated. Naltrexone pellet implantation did not alter the naltrexone-precipitated withdrawal-induced body weight loss. Concurrent naltrexone pellet implantation blocked the naltrexone-precipitated withdrawal-induced hypothermia, increased fecal and urinary output in morphine-dependent rats. 4. These results indicate that a single pellet of 10 mg of naltrexone can effectively block morphine tolerance and physical dependence in the rat. Such a procedure may be useful in studying biochemical, endocrinological and immunological mechanisms involved in opioid addiction processes.