Tremor in Parkinson's disease and serotonergic dysfunction -: An 11C-WAY 100635 PET study
Tremor in Parkinson's disease and serotonergic dysfunction -: An 11C-WAY 100635 PET study
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DOI：
10.1212/01.wnl.0000031424.51127.2b
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发表时间：
2003-02-25
期刊：
影响因子：
9.9
通讯作者：
Brooks, DJ
中科院分区：
文献类型：
--
作者：
Doder, M;Rabiner, EA;Brooks, DJ
背景：帕金森震颤的病理生理机制尚不清楚。对多巴胺能治疗的反应是可变的，非多巴胺能机制可能在震颤产生中起作用。中脑中缝5-HT 1A结合提供了多巴胺能系统完整性的功能测量。通过PET，本研究的目的是检查PD患者局部脑C-11-WAY 100635与5-HT 1A受体的结合，并将其与震颤的严重程度相关联。方法：对23例PD患者和8例年龄匹配的健康志愿者进行C-11-WAY 100635 PET检查。使用小脑参考组织输入函数的房室模型计算脑5-HT 1A受体结合。结果如下：作者发现，与健康志愿者相比，PD患者中脑中缝5-HT 1A结合潜力平均降低27%（p < 0.001）。他们还表明，统一帕金森病评定量表的综合震颤评分，而不是僵硬或运动迟缓，与中缝中的5-HT 1A结合相关（p < 0.01）。结论：这些发现支持了先前的间接证据，即帕金森病在体内的多巴胺能神经传递减少。作者假设，中缝5-HT 1A结合的减少代表受体功能障碍或PD中路易体变性引起的细胞体损失，或两者兼而有之。还发现了中缝核5-HT 1A受体的可用性与帕金森震颤的严重程度之间的关联。
Background: The pathophysiologic mechanisms underlying parkinsonian tremor remain unclear. The response to dopaminergic treatment is variable and nondopaminergic mechanisms may play a role in tremor generation. Midbrain raphe 5-HT1A binding provides a functional measure of serotonergic system integrity. With PET, the aim of this study was to examine regional cerebral C-11-WAY 100635 binding to 5-HT1A receptors in patients with PD and to correlate it with severity of tremor. Methods: C-11-WAY 100635 PET was performed on 23 patients with PD and eight age-matched healthy volunteers. Brain 5-HT1A receptor binding was computed using compartmental modeling with a cerebellar reference tissue input function. Results: The authors found mean 27% reduction in the midbrain raphe 5-HT1A binding potential in patients with PD compared to healthy volunteers (p < 0.001). They also showed that Unified Parkinson's Disease Rating Scale composite tremor scores, but not rigidity or bradykinesia, correlate with 5-HT1A binding in the raphe (p < 0.01). Conclusions: These findings support previous indirect evidence that serotonergic neurotransmission is decreased in PD in vivo. The authors hypothesize that the reduction in raphe 5-HT1A binding represents receptor dysfunction or loss of cell bodies due to Lewy body degeneration in PD, or both. An association between 5-HT1A receptor availability in the raphe and severity of parkinsonian tremor was also found.