Effect of varying frequency, intensity, and pulse duration of transcutaneous electrical nerve stimulation on primary hyperalgesia in inflamed rats
Effect of varying frequency, intensity, and pulse duration of transcutaneous electrical nerve stimulation on primary hyperalgesia in inflamed rats
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DOI：
10.1053/apmr.2000.5576
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发表时间：
2000-07-01
影响因子：
4.3
通讯作者：
Sluka, KA
中科院分区：
文献类型：
--
作者：
Gopalkrishnan, P;Sluka, KA
目的：研究不同频率、强度和脉冲持续时间的经皮电神经刺激（TENS）对大鼠角叉菜胶爪炎症引起的热和机械刺激的原发性痛觉过敏（对伤害性刺激的反应增加）的影响。设计：通过向后爪注射3%角叉菜胶诱导炎症。将两种频率（高，100 Hz;低，4 Hz）、2种强度（高，运动;低，感觉）和2种脉冲持续时间（100 μ sec，250 μ sec）应用于发炎的爪20分钟。在诱导炎症前和诱导炎症后4小时、TENS后以及炎症后8、12和24小时测量对辐射热的缩爪潜伏期（PWL）、对机械刺激的阈值和自发性疼痛相关行为。采用3因素（频率、强度、脉冲持续时间）重复测量（时间）设计分析PWL的变化。机械阈值和自发性疼痛相关的行为进行了比较的频率，强度和脉冲持续时间与Kruskal-Wallis方差analysis of variance.Results：在PWL的变化，热，有一个影响的时间（p = 0.0001）和频率（p = 0.0001），但不是强度（p = 0.45）或脉冲持续时间（p = 0.21）。对于机械阈值的变化，TENS治疗后，频率（p = 0.007）也有影响，但强度（p = 0.055）或脉冲持续时间（p = 0.058）没有影响。与未接受TENS或接受低频TENS治疗的对照组相比，高频TENS显著降低了对热和机械刺激的原发性痛觉过敏。高频运动TENS也减少了自发性疼痛相关的行为为1天后treatment.Conclusion：高频TENS减少原发性痛觉过敏热和机械刺激长达1天后治疗。相反，低频TENS在减少原发性痛觉过敏方面是无效的。不同强度或脉冲持续时间对高频TENS产生的抗痛觉过敏程度没有影响。
Objectives: To examine the effect of varying frequency, intensity, and pulse duration of transcutaneous electrical nerve stimulation (TENS) on primary hyperalgesia (increased response to a noxious stimuli) to heat and mechanical stimuli induced by carrageenan paw inflammation in rats.Design: Inflammation was induced by injection of 3% carrageenan into the hindpaw. Two frequencies (high, 100Hz; low, 4Hz), 2 intensities (high, motor; low, sensory), and 2 pulse durations (100 mu sec, 250 mu sec) were applied for 20 minutes to the inflamed paw. The paw withdrawal latency (PWL) to radiant heat, threshold to mechanical stimuli, and spontaneous pain-related behaviors were measured before and 4 hours after induction of inflammation, after TENS, and at 8, 12, and 24 hours after inflammation. A 3-factor (frequency, intensity, pulse duration) repeated-measures (time) design was used to analyze the changes in PWL. Mechanical threshold and spontaneous pain-related behaviors were compared for frequency, intensity, and pulse duration with a Kruskal-Wallis analysis of variance.Results: For changes in PWL to heat, there was an effect for time (p = .0001) and frequency (p = .0001), but not for intensity (p = .45) or pulse duration (p = .21). For changes in mechanical threshold, there was also an effect for frequency (p = .007), but not for intensity (p = .055) or pulse duration (p = .058), after treatment with TENS. High-frequency TENS significantly reduced the primary hyperalgesia to heat and mechanical stimuli when compared with controls receiving no TENS or treatment with low-frequency TENS. High-frequency motor TENS also reduced spontaneous pain-related behaviors for 1 day after treatment.Conclusion: High-frequency TENS reduces primary hyperalgesia to heat and mechanical stimuli for up to 1 day after treatment. In contrast, low-frequency TENS is ineffective in reducing primary hyperalgesia. Varying intensity or pulse duration had no effect on the degree of antihyperalgesia produced by high-frequency TENS.