Factors predictive of the development of hypothyroidism after intensity-modulated radiation therapy for pharyngeal cancer
Factors predictive of the development of hypothyroidism after intensity-modulated radiation therapy for pharyngeal cancer
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DOI：
10.1080/00016489.2021.1998615
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发表时间：
2021-11-04
影响因子：
1.4
通讯作者：
Nishimura, Yasumasa
中科院分区：
文献类型：
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作者：
Inoue, Eri;Okajima, Kaoru;Nishimura, Yasumasa
背景甲状腺功能减退是头颈部肿瘤放疗后常见的不良反应，由于采用调强放疗（IMRT），其发生率需要重新评估。目的/目的确认甲状腺功能减退症患者咽癌调强放疗的剂量-体积效应。材料与方法回顾性分析2011年6月至2018年5月间接受调强放射治疗的咽癌患者。A组患者（促甲状腺激素（TSH））67%有显着较高的甲状腺功能减退症的发生率。结论及意义：ND和甲状腺V45>67%的咽癌患者有发生甲减的危险。
Background Hypothyroidism is a common adverse event after radiotherapy for head and neck tumors and the incidence need to be re-evaluated because of using intensity-modulated radiotherapy (IMRT). Aims/Objectives Confirm the dose-volume effect of IMRT for pharyngeal cancer on hypothyroidism. Materials and methods This was a retrospective analysis of patients underwent IMRT for pharyngeal cancer from June 2011 to May 2018. Patients were classified into group A (thyroid stimulating hormone (TSH) 67% had a significantly higher incidence of hypothyroidism. Conclusions and significance Patients with pharyngeal cancer who had ND and V45 to the thyroid >67% are at risk of hypothyroidism.