Changes and significance of serum angiopoietin-2 levels in patients with coronary heart disease
Changes and significance of serum angiopoietin-2 levels in patients with coronary heart disease
复制标题
冠心病患者血清血管生成素2水平的变化及意义
DOI：
10.3109/1354750x.2012.727028
复制
发表时间：
2012-12-01
期刊：
影响因子：
2.6
通讯作者：
Zhang, Yongzhen
中科院分区：
文献类型：
--
作者：
Wang, Xin;Yong, Huijuan;Zhang, Yongzhen
冠心病是以炎症过程和内皮功能障碍为特征的疾病。为了研究血管生成素-2(Ang-2)的变化规律，我们对166例不同类型冠心病患者的血清Ang-2水平进行了测定。采用酶联免疫吸附试验检测血管紧张素转换酶-2的含量。冠心病患者血清Ang-2水平明显升高，并随着冠心病的进展逐渐升高。Ang-2与Gensini评分、hs-CRP呈正相关。Ang-2在检测和监测冠心病的进展方面可能有潜在的应用价值。
Coronary heart disease (CHD) is characterized by inflammatory process and endothelial dysfunction. To investigate angiopoietin-2 (Ang-2) profiles, we evaluated serum Ang-2 levels in different types of CHD in 166 subjects. Ang-2 was measured by enzyme-linked immunosorbent assay. Serum Ang-2 levels were significantly elevated in patients with CHD and gradually increased with advance of CHD. Ang-2 was positively correlated with Gensini scores and hs-CRP. Ang-2 might have potential implication in detecting and monitoring the progression of CHD.