Synthesis of Magnetic, Up-Conversion Luminescent, and Mesoporous Core-Shell-Structured Nanocomposites as Drug Carriers
Synthesis of Magnetic, Up-Conversion Luminescent, and Mesoporous Core-Shell-Structured Nanocomposites as Drug Carriers
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作为药物载体的磁性、上转换发光和介孔核壳结构纳米复合材料的合成
DOI：
10.1002/adfm.200902274
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发表时间：
2010-04-09
影响因子：
19
通讯作者：
Lin, Jun
中科院分区：
文献类型：
--
作者：
Gai, Shili;Yang, Piaoping;Lin, Jun
报道了单分散核壳结构 Fe3O4@nSiO(2)@mSiO(2)@NaYF4: Yb3+ 的合成（通过简单的两步溶胶-凝胶法）、表征和在药物控制释放中的应用。具有介孔、上转换发光和磁性的 Er3+/Tm3+ 纳米复合材料。纳米复合材料表现出典型的有序介孔特征和具有窄尺寸分布（约80 nm）的单分散球形形态。此外，即使在负载药物分子后，它们在980 nm激光激发下也表现出高磁化强度（38.0 emu g(-1)，因此可以在外磁场下进行药物靶向）和独特的上转换发射（Yb3+/Er3+为绿色，Yb3+/Tm3+为蓝色）。药物释放测试表明多功能纳米复合材料具有受控药物释放特性。有趣的是，多功能载体的上转换发射强度随着模型药物的释放量而增加，从而可以通过光致发光强度的变化来监测和跟踪释放过程。该复合材料可以作为多功能药物载体系统，同时实现药物的靶向和监测。
The synthesis (by a facile two-step sol-gel process), characterization, and application in controlled drug release is reported for monodisperse coreshell-structured Fe3O4@nSiO(2)@mSiO(2)@NaYF4: Yb3+; Er3+/Tm3+ nanocomposites with mesoporous, up-conversion luminescent, and magnetic properties. The nanocomposites show typical ordered mesoporous characteristics and a monodisperse spherical morphology with narrow size distribution (around 80 nm). In addition, they exhibit high magnetization (38.0 emu g(-1), thus it is possible for drug targeting under a foreign magnetic field) and unique up-conversion emission (green for Yb3+/Er3+ and blue for Yb3+/Tm3+) under 980 nm laser excitation even after loading with drug molecules. Drug release tests suggest that the multifunctional nanocomposites have a controlled drug release property. Interestingly, the up-conversion emission intensity of the multifunctional carrier increases with the released amount of model drug, thus allowing the release process to be monitored and tracked by the change of photoluminescence intensity. This composite can act as a multifunctional drug carrier system, which can realize the targeting and monitoring of drugs simultaneously.