Prevalence of Taenia solium cysticercosis in swine from a community-based study in 21 villages of the Eastern Cape Province, South Africa
Prevalence of Taenia solium cysticercosis in swine from a community-based study in 21 villages of the Eastern Cape Province, South Africa
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DOI：
10.1016/j.vetpar.2008.03.005
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发表时间：
2008-06-14
影响因子：
2.6
通讯作者：
Willingham, A. L., III
中科院分区：
文献类型：
--
作者：
Krecek, R. C.;Michael, L. M.;Willingham, A. L., III
猪绦虫是猪囊虫病和人类脑囊虫病的病原体，已知在包括东开普省在内的南非一些地区发生，但尽管关于其在整个分区域发生的报告越来越多，但其流行率尚未明确确定。该寄生虫在流行地区造成了潜在的严重农业问题和公共卫生风险。被认为感染这种人畜共患蠕虫风险最高的人群是生活在农村地区的人，其中大多数人完全或部分通过饲养牲畜谋生。在这里，我们报告的初步结果，以社区为基础的研究所拥有的资源贫乏，新兴的养猪生产者从21个村庄在东开普省的猪。采用活体猪舌检（舌触诊）、两种检测寄生虫抗原的酶联免疫吸附试验（ELISA）（B 158/B60 Ag-ELISA和HP 10 Ag-ELISA）和一种检测抗寄生虫抗体的酶免疫转移印迹试验（EIT B）来验证流行性并估计表观流行率。在没有金标准的情况下，使用贝叶斯方法，使用现有数据和先验信息的模型，获得了真实的患病率。结果表明，寄生虫确实存在于研究村庄，真正的患病率为64.6%。四种方法的表观患病率分别为：舌检11.9%，B158/B60 Ag-ELISA 54.8%，HP 10 Ag-ELISA 40.6%，EITB 33.3%。猪体内猪囊虫病流行的基本知识为设计和监测可持续和适当的囊虫病预防和控制干预措施提供了必要的信息。(c)2008 Elsevier B. V.保留所有权利。
The pork tapeworm, Taenia solium, causative organism of porcine cysticercosis and human neurocysticercosis is known to occur in areas of South Africa including Eastern Cape Province but, despite increasing reports of its occurrence throughout the subregion, the prevalence is yet to be clearly established. The parasite presents a potentially serious agricultural problem and public health risk in endemic areas. The human populations considered to be at highest risk of infection with this zoonotic helminth are people living in rural areas most of whom earn their livelihood wholly or partially through livestock rearing. Here we report on initial results of a community-based study of pigs owned by resource-poor, emerging pig producers from 21 villages in the Eastern Cape Province. Lingual examination (tongue palpation) in live pigs, two enzyme-linked immunosorbent assays (ELISAs), which detect parasite antigen (B 158/B60 Ag-ELISA and HP10 Ag-ELISA) and an enzyme immunotransfer blot (EITB) assay, which detects antiparasite antibody, were used to verify endemicity and estimate apparent prevalence. In the absence of a gold standard true prevalence was obtained, using a Bayesian approach, with a model that uses both available data and prior information. Results indicate that the parasite is indeed present in the study villages and that true prevalence was 64.6%. The apparent prevalences as measured by each of the four tests were: 11.9% for lingual examination, 54.8% for B158/B60 Ag-ELISA, 40.6% for HP10 Ag-ELISA and 33.3% for EITB. This base-line knowledge of the prevalence of T solium in pigs provides information essential to the design and monitoring of sustainable and appropriate interventions for cysticercosis prevention and control. (c) 2008 Elsevier B.V. All rights reserved.