On the number of ancestors to a DNA sequence.

On the number of ancestors to a DNA sequence.
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关于DNA序列的祖先数量。

DOI:
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发表时间:
1997
期刊:
影响因子:
3.3
通讯作者:
Jotun Hein
Jotun Hein
中科院分区:
生物学2区
文献类型:
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作者:
Carsten Wiuf;Jotun Hein

文献摘要

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如果一个群体中的同源序列不经历重组,它们都可以追溯到一个祖先序列。然而,我们基因组的其余部分会进行重组,并将在一系列个体上传播。祖先的物质分布到现存的染色体在这里调查的合并与重组,并讨论了相对于人类的结果。在一个实际规模为130万的祖先人口中,少于6.4%的少数人将携带任何现代人类祖先的物质。估计实际人口规模可能更高,为500万,将百分比降至1.7%。
If homologous sequences in a population are not subject to recombination, they can all be traced back to one ancestral sequence. However, the rest of our genome is subject to recombination and will be spread out on a series of individuals. The distribution of ancestral material to an extant chromosome is here investigated by the coalescent with recombination, and the results are discussed relative to humans. In an ancestral population of actual size 1.3 million a minority of <6.4% will carry material ancestral to any present human. The estimated actual population size can be even higher, 5 million, reducing the percentage to 1.7%.