Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms
Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms
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DOI：
10.1016/j.bbrc.2007.08.012
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发表时间：
2007-10-12
影响因子：
3.1
通讯作者：
Goto, Hidemi
中科院分区：
文献类型：
--
作者：
Ishiguro, Kazuhiro;Ando, Takafumi;Goto, Hidemi
生姜在世界范围内被用作香料、食品和传统草药，我们发现从生姜中分离的酚烷酮6-姜辣素可增强TRAIL诱导的胃癌细胞活力降低，而单独的6-姜辣素对胃癌细胞活力的影响很小。6-姜辣素通过增加TRAIL诱导的caspase-3/7活化促进TRAIL诱导的细胞凋亡。6-姜辣素通过抑制TRAIL诱导的NF-κ B活化，下调cIAPI的表达，cIAPI抑制caspase-3/7活性。由于6-姜烯酚具有与6-姜辣素相似的化学结构，我们还评估了6-姜烯酚对胃癌细胞活力的影响。与6-姜辣素不同，单独使用6-姜烯酚会降低胃癌细胞的存活率。6-Shogaol显示出损伤微管并诱导有丝分裂停滞。这些发现首次表明，在胃癌细胞中，6-姜辣素通过抑制TRAIL诱导的NF-κ B活化来增强TRAIL诱导的生存力降低，而单独的6-姜烯酚通过破坏微管来降低生存力。(C)2007爱思唯尔公司All rights reserved.
Ginger has been used throughout the world as spice, food and traditional herb. We found that 6-gingerol, a phenolic alkanone isolated from ginger, enhanced the TRAIL-induced viability reduction of gastric cancer cells while 6-gingerol alone affected viability only slightly. 6-Gingerol facilitated TRAIL-induced apoptosis by increasing TRAIL-induced caspase-3/7 activation. 6-Gingerol was shown to down-regulate the expression of cIAPI, which suppresses caspase-3/7 activity, by inhibiting TRAIL-induced NF-kappa B activation. As 6-shogaol has a chemical structure similar to 6-gingerol, we also assessed the effect of 6-shogaol on the viability of gastric cancer cells. Unlike 6-gingerol, 6-shogaol alone reduced the viability of gastric cancer cells. 6-Shogaol was shown to damage microtubules and induce mitotic arrest. These findings indicate for the first time that in gastric cancer cells, 6-gingerol enhances TRAIL-induced viability reduction by inhibiting TRAIL-induced NF-kappa B activation while 6-shogaol alone reduces viability by damaging microtubules. (C) 2007 Elsevier Inc. All rights reserved.