Precession measurement of perturbed angular correlation in double-photon emission nuclides with magnetic field for novel RI imaging method
Precession measurement of perturbed angular correlation in double-photon emission nuclides with magnetic field for novel RI imaging method
复制标题
新型RI成像方法中磁场双光子发射核素扰动角相关性的进动测量
DOI：
10.1016/j.nima.2023.168122
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Takahashi Hiroyuki
中科院分区：
文献类型：
--
作者：
Ueki Taisei;Uenomachi Mizuki;Shimazoe Kenji;Tomita Hideki;Kamada Kei;Takahashi Hiroyuki
核医学成像技术，如单光子发射计算机断层扫描和正电子发射断层扫描，是医学领域中重要和敏感的诊断方法。这些技术用于使用伽马射线测量和可视化放射性标记分子的积累。在以前的研究中，我们研究了一种新的方法，双光子发射成像，利用级联核素与级联γ射线。该方法通过发射的伽马射线的时空相关性帮助提取关于核周围的局部微环境的信息，诸如pH和化学状态（Shimazoe等人，2022年）。在这项研究中，我们使用了一个磁场作为外场诱导拉莫尔进动的磁场和特点的影响，在液态级联放射性同位素。我们设计了8个GAGG-MPPC 8 × 8（共512个通道）阵列探测器，采用各自的时间过阈值读出系统，形成一个环形，并表征了111 In水溶液在磁场作用下γ射线发射方向的角相关性。测量并表征了磁场的存在和强度（从0到3 T）对角关联的影响。讨论了一种用于估计源的位置的方法，该方法使用的事实是，关于施加到源的磁场的强度的信息可以从伽马辐射读数计算。
Nuclear medical imaging techniques such as single-photon emission computed tomography and positron emission tomography, are important and sensitive diagnostic methods in the field of medicine. These techniques are used to measure and visualize the accumulation of radiolabeled molecules using gamma rays. In a previous study, we investigated a novel method, double-photon emission imaging, by utilizing cascade nuclides with cascade gamma rays. This method helps extract information regarding the local microenvironment, such as pH and chemical state, around a nucleus through the time–space correlation of emitted gamma rays (Shimazoe et al., 2022). In this study, we used a magnetic field as the external field for inducing Larmor precession by the magnetic field and characterized the effect in a liquid-state cascade radioisotope. We designed eight GAGG-MPPC 8 × 8 (512 channels in total) array detectors using an individual time-over-threshold readout system to form a ring and characterize the angular correlation of the direction of gamma-ray emission of an aqueous solution of111In caused by the magnetic field. The impact of the existence and strength of the magnetic field (from 0 to 3T) on the angular correlation were measured and characterized. A method for estimating the location of the source was discussed using the fact that information on the strength of the magnetic field applied to the source can be calculated from the gamma radiation readings.