Emergence in Asia of foot-and-mouth disease viruses with altered host range: Characterization of alterations in the 3A protein
Emergence in Asia of foot-and-mouth disease viruses with altered host range: Characterization of alterations in the 3A protein
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DOI：
10.1128/jvi.75.3.1551-1556.2001
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发表时间：
2001-02-01
影响因子：
5.4
通讯作者：
Mason, PW
中科院分区：
文献类型：
--
作者：
Knowles, NJ;Davies, PR;Mason, PW
1997年，中国台湾省发生了一起由O型口蹄疫病毒引起的动物流行病，感染的是猪，而不是牛。该病毒有一个改变的3A蛋白，其中包含10个氨基酸的缺失和一系列的替换。在这里，我们发现这种缺失存在于该地区最早的O型病毒中（从1970年开始），而缺失周围的替换是在过去29年中积累起来的。对这些病毒在牛细胞中生长的分析表明，除了缺失外，基因组本身的变化是造成该谱系中当前亚洲病毒嗜猪特性的原因。
In 1997, an epizootic in Taiwan, Province of China, was caused by a type O foot-and-mouth disease virus which infected pigs but not cattle. The virus had an altered 3A protein, which harbored a 10-amino acid deletion and a series of substitutions. Here we show that this deletion is present in the earliest type O virus examined from the region (from 1970), whereas substitutions surrounding the deletion accumulated over the last 29 years. Analyses of the growth of these viruses in bovine cells suggest that changes in the genome in addition to the deletion, per se, are responsible for the porcinophilic properties of current Asian viruses in this lineage.