Radial organization of developing preterm human cerebral cortex revealed by non-invasive water diffusion anisotropy MRI
Radial organization of developing preterm human cerebral cortex revealed by non-invasive water diffusion anisotropy MRI
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DOI：
10.1093/cercor/12.12.1237
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发表时间：
2002-12-01
期刊：
影响因子：
3.7
通讯作者：
Neil, JJ
中科院分区：
文献类型：
--
作者：
McKinstry, RC;Mathur, A;Neil, JJ
大脑皮层的发育涉及一系列复杂的事件，这些事件在完整的活体中很难可视化。在这项研究中，我们应用扩散张量成像（DTI）的人类婴儿从26至41周胎龄（GA）的皮质发育的评价。在26周GA时，皮质中水的表观扩散是最大的各向异性，并且到36周GA时各向异性值接近于零。在此期间，在大脑皮层的扩散张量的主要特征向量是径向跨皮质板，在雅阁的主要径向部署的神经元成分。旋转平均水扩散系数的值增加之间的26和32周GA，然后降低。DTI参数的这些变化是大脑皮层特有的，反映了底层皮层结构和神经元连接形成的变化。由于其与组织微结构和非侵入性的相关性，DTI提供了对早产儿大脑皮层发育的独特见解，并可能检测其基本细胞结构的紊乱。
Cerebral cortical development involves a complex cascade of events which are difficult to visualize in intact, living subjects. In this study, we apply diffusion tensor imaging (DTI) to the evaluation of cortical development in human infants ranging from 26 to 41 weeks gestational age (GA). Apparent diffusion of water in cortex is maximally anisotropic at 26 weeks GA and anisotropy values approach zero by 36 weeks GA. During this period, the major eigenvector of the diffusion tensor in cerebral cortex is oriented radially across the cortical plate, in accord with a predominately radial deployment of its neuronal constituents. Values for the rotationally averaged water diffusion coefficient increase between 26 and 32 weeks GA, then decrease thereafter. These changes in DTI parameters are specific to cerebral cortex and reflect changes in underlying cortical architecture and formation of neuronal connections. Because of its correlation with tissue microstructure and non-invasive nature, DTI offers unique insight into cortical development in preterm human newborns and, potentially, detection of derangements of its basic cytoarchiteture.