Assessment of cortical and trabecular bone changes in two models of post-traumatic osteoarthritis.
Assessment of cortical and trabecular bone changes in two models of post-traumatic osteoarthritis.
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DOI：
10.1002/jor.22975
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Haut Donahue TL
中科院分区：
文献类型：
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作者：
Pauly HM;Larson BE;Coatney GA;Button KD;DeCamp CE;Fajardo RS;Haut RC;Haut Donahue TL
软骨下骨被认为在创伤后骨关节炎的发生和发展中起重要作用。本研究的目的是记录前交叉韧带损伤的两种Lapine模型、改良的前交叉韧带横断模型和闭合关节创伤压缩撞击模型对胫骨和股骨软骨下骨的影响。用微型计算机断层扫描技术扫描损伤后12周的骨骼。两种模型的患肢软骨下骨体积和骨密度均降低。手术横断动物主要表现为股骨和胫骨的内侧半关节有明显的骨质改变，而创伤撞击动物的两个骨骼的内侧和外侧半关节都有明显的改变。据认为，内侧半关节软骨下骨的改变可能是由两种模型中所见的软组织结构受损引起的。创伤性撞击动物外侧半关节软骨下骨的改变被认为是由于压缩冲击力通过关节传递所致。创伤撞击模型中显示的关节范围的骨骼变化与研究人类骨关节炎进展的临床研究结果相似。
Subchondral bone is thought to play a significant role in the initiation and progression of the post-traumatic osteoarthritis. The goal of this study was to document changes in tibial and femoral subchondral bone that occur as a result of two lapine models of anterior cruciate ligament injury, a modified ACL transection model and a closed-joint traumatic compressive impact model. Twelve weeks post-injury bones were scanned via micro-computed tomography. The subchondral bone of injured limbs from both models showed decreases in bone volume and bone mineral density. Surgical transection animals showed significant bone changes primarily in the medial hemijoint of femurs and tibias, while significant changes were noted in both the medial and lateral hemijoints of both bones for traumatic impact animals. It is believed that subchondral bone changes in the medial hemijoint were likely caused by compromised soft tissue structures seen in both models. Subchondral bone changes in the lateral hemijoint of traumatic impact animals are thought to be due to transmission of the compressive impact force through the joint. The joint-wide bone changes shown in the traumatic impact model were similar to clinical findings from studies investigating the progression of osteoarthritis in humans.