Modeling chemotaxis of adhesive cells: stochastic lattice approach and continuum description
Modeling chemotaxis of adhesive cells: stochastic lattice approach and continuum description
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DOI：
10.1088/1367-2630/16/2/025002
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发表时间：
2014-02-07
影响因子：
3.3
通讯作者：
Khain, Evgeniy
中科院分区：
文献类型：
--
作者：
Charteris, Nicholas;Khain, Evgeniy
采用两种方法：通过求解细胞动力学的随机离散晶格模型和推导并求解细胞密度的连续宏观方程，分析了趋化性对粘附和增殖细胞在基底上迁移的影响。正面传播的现象进行了调查的框架内的两种方法，积极和消极的趋化性。格子模型和连续体模型的结果之间的一个很好的协议观察到的前速度和前配置文件。理论模型也能够匹配最近的实验观察神经胶质瘤细胞迁移。
The effect of chemotaxis on migration of adhesive and proliferative cells on a substrate is analyzed by employing two approaches: by solving a stochastic discrete lattice model for cell dynamics and by deriving and solving a continuum macroscopic equation for cell density. The phenomenon of front propagation is investigated in the framework of the two approaches both for positive and negative chemotaxis. A good agreement between the results of the lattice model and of the continuum model is observed both for front velocities and front profiles. The theoretical model is also able to match recent experimental observations on glioma cell migration.