Man as living bioreactor:: Fate of an exogenously prepared customized tissue-engineered mandible
Man as living bioreactor:: Fate of an exogenously prepared customized tissue-engineered mandible
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DOI：
10.1016/j.biomaterials.2006.01.050
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发表时间：
2006-06-01
期刊：
影响因子：
14
通讯作者：
Terheyden, H
中科院分区：
文献类型：
--
作者：
Warnke, PH;Wiltfang, J;Terheyden, H
2004年，我们报道了利用活体组织工程技术修复人下颌骨的新方法。患者作为自己的生物反应器，因为外部准备的定制下颌骨置换在移植之前种植在他的背阔肌内，以修复现有的缺陷。我们的技术是通过丰富的动物模型经验开发出来的。我们描述了我们和病人在这一过程中的经验。我们给出了这项技术的好处和局限性的细节，并概述了在未来的人类临床试验中应该解决的问题。(C)2006爱思唯尔有限公司。保留所有权利。
In 2004, we reported it novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials. (c) 2006 Elsevier Ltd. All rights reserved.