The concept of immune surveillance against tumors. The first theories.
The concept of immune surveillance against tumors. The first theories.
复制标题
DOI：
10.18632/oncotarget.12739
复制
发表时间：
2017-01-24
期刊：
影响因子：
--
通讯作者：
Ribatti D
中科院分区：
文献类型：
--
作者：
Ribatti D
免疫系统在肿瘤监测中发挥着重要作用。为了避免免疫系统的攻击，肿瘤细胞会制定不同的策略来逃避免疫监视。免疫监视的证据来自动物模型和临床观察。患有多种免疫缺陷的小鼠肿瘤发病率很高，并且更容易受到移植或化学致癌物诱发的肿瘤的影响。免疫抑制的患者肿瘤发病率很高。然而，许多患者即使在免疫系统明显正常的情况下也会患上癌症。这表明肿瘤细胞能够逃避免疫监视。本文旨在总结有关肿瘤免疫监视理论发展的文献；讨论支持和反对该理论的证据，并讨论免疫编辑的概念。最后，对当前抗肿瘤免疫治疗的方法进行分析。
The immune system plays a major role in the surveillance against tumors. To avoid attack from the immune system, tumor cells develop different strategies to escape immune surveillance. Evidence of immune surveillance comes from both animal models and clinical observations. Mice with a wide variety of immunodeficiencies have a high rate of tumor incidence and are more susceptible to transplanted or chemical carcinogen-induced tumors. Immunosuppressed patients have a high incidence of tumors. However, many patients develop cancer even in the presence of an apparently normal immune system. This indicates that tumor cells are able to escape immune surveillance. The aim of this review article is to summarize the literature concerning the development of the theory of immune surveillance against tumors; to discuss the evidence for and against this theory, and to discuss the concept of immunoediting. Finally, the current approaches in anti-tumor immunotherapy will be analyzed.