Anti-inflammatory activity of nanocrystalline silver in a porcine contact dermatitis model
Anti-inflammatory activity of nanocrystalline silver in a porcine contact dermatitis model
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DOI：
10.1016/j.nano.2008.04.006
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发表时间：
2008-09-01
影响因子：
5.4
通讯作者：
Burrell, Robert E.
中科院分区：
文献类型：
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作者：
Nadworny, Patricia L.;Wang, JianFei;Burrell, Robert E.
使用猪接触性皮炎模型检查纳米晶银的抗炎活性。用二硝基氯苯诱导炎症，然后每天用纳米晶银敷料、0.5%硝酸银或生理盐水治疗。红斑、水肿和组织学数据显示，纳米晶银处理的猪在72小时后具有接近正常的皮肤，而其他处理组仍然发炎。纳米晶银治疗组的炎症减少与炎性细胞凋亡增加、促炎细胞因子表达减少和明胶酶活性降低相关。银硝酸盐处理诱导所有细胞类型中的细胞凋亡，包括角质形成细胞，导致伤口愈合延迟。这些结果表明，纳米晶银在猪接触性皮炎模型中具有直接的抗炎作用，改善了愈合过程的总体结果。这些数据提供了支持，一种银（e.例如，在一个实施例中，与纳米晶银独特相关的纳米晶银（Ag-0）可能是抗炎活性和愈合改善的原因。(C)2008年爱思唯尔公司All rights reserved.
The anti-inflammatory activity of nanocrystalline silver was examined using a porcine model of contact dermatitis. Inflammation was induced with dinitrochlorobenzene and then treated daily with nanocrystalline silver dressings, 0.5% silver nitrate, or saline. Erythema, edema, and histological data showed that nanocrystalline silver-treated pigs had near-normal skin after 72 hours, while other treatment groups remained inflamed. The decreased inflammation in the nanocrystalline silver-treated group was associated with increased inflammatory cell apoptosis, a decreased expression of proinflammatory cytokines, and decreased gelatinase activity. Silver nitrate treatments induced apoptosis in all cell types, including keratinocytes, resulting in delayed wound healing. These results demonstrate that nanocrystalline silver had a direct anti-inflammatory effect in the porcine contact dermatitis model that improved the overall outcome of the healing process. These data offer support that a species of silver (e. g., Ag-0) that is uniquely associated with nanocrystalline silver may be responsible for the anti-inflammatory activity and improvement in healing. (C) 2008 Elsevier Inc. All rights reserved.