Technology in cancer research and treatment
Technology in cancer research and treatment
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DOI：
10.1177/153303460700600401
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发表时间：
2007-08-01
影响因子：
2.8
通讯作者：
Rubinsky, Boris
中科院分区：
文献类型：
--
作者：
Rubinsky, Boris
这是对医学中新兴的不可逆电穿孔领域的简要介绍。当在整个细胞中施加某些电场时，可能通过在细胞膜中形成纳米级的缺陷，从而使细胞膜的透过性成为唯一的效应。有时，这个过程会导致细胞死亡，主要是当电场导致膜永久通透，从而导致细胞动态平衡丧失时，这一过程被称为不可逆电穿孔。这是一种不寻常的细胞死亡模式，目前还不清楚。虽然不可逆的电穿孔现象可能已经被知道了几个世纪，但直到最近才在医学上被严格考虑用于组织消融的各种应用。简要介绍了不可逆电穿孔的历史，并对该领域的最新研究进行了讨论。
This is a brief introduction to the emerging field of irreversible electroporation in medicine. Certain electrical fields when applied across a cell can have as a sole effect the permeabilization of the cell membrane, presumable through the formation of nanoscale defects in the cell membrane. Sometimes this process leads to cell death, primarily when the electrical fields cause permanent permeabilization of the membrane and the consequent loss of cell homeostasis, in a process known as irreversible electroporation. This is an unusual mode of cell death that is not understood yet. While the phenomenon of irreversible electroporation may have been known for centuries it has become only recently rigorously considered in medicine for various applications of tissue ablation. A brief historical perspective of irreversible electroporation is presented and recent studies in the field are discussed.