Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic Protoporphyria
Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic Protoporphyria
复制标题
红细胞膜中胆固醇氢过氧化物的形成和红细胞生成性原卟啉症的光溶血作用
作者：
A. Lamola;T. Yamane;A. M. Trozzolo
3β-羟基-5 α-氢过氧-Δ6-胡萝卜素是在含原卟啉的红细胞血影中产生的，在氧气存在下用约400 nm的光照射。这种胆固醇光氧化产物掺入正常红细胞导致渗透脆性增加，最终导致溶血。这些结果可能与红细胞生成性原卟啉症相关的光溶血有关。
3β-Hydroxy-5α-hydroperoxy-Δ6-cholestene is produced in protoporphyrin-containing red blood cell ghosts irradiated with approximately 400-nanometer light in the presence of oxygen. Incorporation of this cholesterol photooxidation product into normal red blood cells leads to increased osmotic fragility and eventual hemolysis. These results may be relevant to photohemolysis associated with erythropoietic protoporphyria.