Controlled drug release from hydrogel nanoparticle networks
Controlled drug release from hydrogel nanoparticle networks
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DOI：
10.1016/j.jconrel.2003.10.007
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发表时间：
2004-02-10
影响因子：
10.8
通讯作者：
Moro, D
中科院分区：
文献类型：
--
作者：
Huang, G;Gao, J;Moro, D
合成了单分散聚N-异丙基丙烯酰胺-共烯丙基胺(PNIPAM-co-Altylamine)和PNIPAM-co-AA(PNIPAM-co-AA)纳米粒子。在室温和中性pH条件下，分别以戊二醛和己二酸二肼为交联剂，将紧密堆积的PNIPAM-共烯丙胺和PNIPAM-co-AA纳米粒子进行共价交联，形成三维凝胶网络。以不同相对分子质量的葡聚糖标记物为模型大分子药物进行控释研究。在不同的物理条件下，包括温度范围和葡聚糖分子量，对药物的释放进行了量化。葡聚糖被包裹在纳米颗粒网络的空腔中，其释放速度受其分子量和空腔大小的控制。观察到具有高交联度的传统块状PNIPAM凝胶中的NO释放。PNIPAM-co-烯丙基胺网络的释药速率具有温度依赖性，室温下的释药速度远快于人体温度。相反，低分子右旋糖苷从PNIPAM-co-AA网络中的释放呈现温度无关的释放曲线。这些纳米颗粒网络在控制高分子生物分子的释放方面比传统的块状GET有几个优点。(C)2003爱思唯尔B.V.保留所有权利。
Monodisperse nanoparticles of poly-N-isopropylacrylamide-co-allylamine (PNIPAM-co-altylamine) and PNIPAM-co-acrylic acid (PNIPAM-co-AA) were synthesized. The close-packed PNIPAM-co-allylamine and PNIPAM-co-AA nanoparticles were converted to three-dimensional gel networks by covalently crosslinking neighboring particles at room temperature and neutral pH using glutaric dialdehyde and adipic acid dihydrazide, respectively. Controlled release studies were conducted using dextran markers of various molecular weights as model macromolecular drugs. Release was quantified under various physical conditions, including a range of temperatures and dextran molecular weights. Dextran, entrapped in cavities in the nanoparticle network, was released with a rate regulated by their molecular weights and cavity size. No release from a conventional bulk PNIPAM gel, with high crosslinking density, was observed. The rate of release from the PNIPAM-co-allylamine network was temperature-dependant, being much faster at room temperature than that at human body temperature. In contrast, release of low molecular weight dextrans from the PNIPAM-co-AA network showed a temperature-independent release profile. These nanoparticle networks have several advantages over conventional bulk gets for controlling the release of high molecular weight biomolecules. (C) 2003 Elsevier B.V. All rights reserved.