Circulating ACTH and related peptides in lung cancer.
Circulating ACTH and related peptides in lung cancer.
复制标题
肺癌中循环ACTH和相关肽。
DOI：
10.1038/bjc.1982.38
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发表时间：
1982-02
影响因子：
8.8
通讯作者：
Gropp, C
中科院分区：
文献类型：
--
作者：
Ratcliffe, J G;Podmore, J;Stack, B H;Spilg, W G;Gropp, C
在134例肺癌患者中测定了高水平循环ACTH样免疫活性的患病率，参考范围来自52例年龄和性别匹配的非恶性肺病患者。两项研究使用了不同特异性的ACTH放射免疫测定法。研究A使用未提取的血浆或血清测定总ACTH免疫活性。高血清ACTH水平发生在24%的小细胞癌患者和3%的非小细胞癌患者。在小细胞癌患者中，12%的局限性疾病和32%的广泛性疾病的水平较高。研究B在通过多孔玻璃提取血浆后使用ACTH测定，其主要测量常规1-39 ACTH。这里没有肺癌患者的水平高于参考范围，这表明研究A中的高水平可能是由于多孔玻璃提取不良的血浆ACTH成分。它的结论是，高循环ACTH免疫活性发生在少数肺癌患者，特别是那些广泛的小细胞癌。间接证据表明，高水平的ACTH检测与总ACTH是由于分子形式以外的1-39 ACTH，可能是高摩尔。wt物种。
The prevalence of high levels of circulating ACTH-like immunoactivity was determined in 134 patients with lung cancer, using reference ranges from 52 age- and sex-matched patients with non-malignant lung disease. Two studies used ACTH radioimmunoassays with different specificities. Study A used an unextracted plasma or serum assay for total ACTH immunoactivity. High serum ACTH levels occurred in 24% of patients with small-cell carcinoma and 3% of patients with non-small-cell cancer. In patients with small-cell carcinoma, levels were high in 12% with limited disease and 32% with extensive disease. Study B used an ACTH assay after plasma extraction by porous glass, which measured mainly regular 1-39 ACTH. Here no lung-cancer patient had levels above the reference range, suggesting that the high levels in Study A may be due to plasma ACTH components which are poorly extracted by porous glass. It is concluded that high circulating ACTH immunoactivity occurs in a minority of patients with lung cancer, particularly those with extensive small-cell carcinoma. Indirect evidence suggests that the high ACTH levels detected with assays for total ACTH are due to molecular forms other than 1-39 ACTH, probably high-mol.-wt species.