Web-based survey of fertility issues in young women with breast cancer
Web-based survey of fertility issues in young women with breast cancer
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DOI：
10.1200/jco.2004.01.159
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发表时间：
2004-10-15
影响因子：
45.3
通讯作者：
Winer, EP
中科院分区：
文献类型：
--
作者：
Partridge, AH;Gelber, S;Winer, EP
目的\年轻乳腺癌患者经常寻求治疗是否会影响生育能力的建议。我们试图更好地了解妇女对生育的态度，以及这些问题如何影响decisionmaking.Patients和Methods我们开发了一个关于生育问题的年轻女性的早期乳腺癌史的调查。调查通过电子邮件发送给所有登记的青年生存联盟幸存者成员（N = 1 702）。结果六百五十七个合格的受访者完成了调查。乳腺癌诊断时的平均年龄为32.9岁;平均当前年龄为35.8岁。90%的女性是白色; 62%已婚; 76%是大学毕业生。诊断分期如下：0，10%; I，27%; Il，47%; III，13%。62%的女性在诊断后2年内。57%的人回忆起在诊断时对治疗后不孕的严重担忧。在多变量logistic回归分析中，对不孕症的更多关注与想要孩子/更多孩子（比值比[OR]，120; P <0.0001），先前怀孕次数（OR，0.78; P = 0.01）和先前难以怀孕（OR，1.86; P = 0.08）相关。29%的妇女报告说，不孕症的担忧影响了治疗决定。72%的女性报告与医生讨论了生育问题; 51%的人认为他们的担忧得到了充分的解决。妇女似乎高估了他们的风险成为绝经后treatment.Conclusion治疗后的生育能力是一个主要关注的年轻女性乳腺癌。有必要在诊断时与年轻患者沟通并教育他们有关生育问题，并需要进一步研究以保护年轻乳腺癌幸存者的生育能力。(C)2004年，美国临床肿瘤学会。
Purpose \Young women with breast cancer often seek advice about whether treatment will affect their fertility. We sought to gain a better understanding of women's attitudes about fertility and how these concerns affect decision making.Patients and Methods We developed a survey about fertility issues for young women with a history of early-stage breast cancer. The survey was e-mailed to all registered Young Survival Coalition survivor members (N = 1,702). E-mail reminders were used.Results Six hundred fifty-seven eligible respondents completed the survey. Mean age at breast cancer diagnosis was 32.9 years; mean current age was 35.8 years. Ninety percent of women were white; 62% were married; 76% were college graduates. Stages at diagnosis were as follows: 0, 10%; I, 27%; Il, 47%; III, 13%. Sixty-two percent of women were within 2 years of diagnosis. Fifty-seven percent recalled substantial concern at diagnosis about becoming infertile with treatment. In multivariate logistic regression, greater concern about infertility was associated with wish for children/more children (odds ratio [OR], 120; P < .0001), number of prior pregnancies (OR, 0.78; P = .01), and prior difficulty conceiving (OR, 1.86; P = .08). Twenty-nine percent of women reported that infertility concerns influenced treatment decisions. Seventy-two percent of women reported discussing fertility concerns with their doctors; 51 % felt their concerns were addressed adequately. Women seemed to overestimate their risk of becoming postmenopausal with treatment.Conclusion Fertility after treatment is a major concern for young women with breast cancer. There is a need to communicate with and educate young patients regarding fertility issues at diagnosis and a need for future research directed at preserving fertility for young breast cancer survivors. (C) 2004 by American Society of Clinical Oncology.