Serum levels of androstenedione, testosterone and dehydroepiandrosterone sulfate in patients with premature ovarian failure to age-matched menstruating controls
Serum levels of androstenedione, testosterone and dehydroepiandrosterone sulfate in patients with premature ovarian failure to age-matched menstruating controls
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DOI：
10.1159/000291817
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发表时间：
1997-01-01
影响因子：
2.1
通讯作者：
Rojas, FJ
中科院分区：
文献类型：
--
作者：
Elias, AN;Pandian, MR;Rojas, FJ
在 29 名卵巢早衰 (POF) 患者和相同数量的年龄匹配的正常对照受试者中测量了雄烯二酮、睾酮和硫酸脱氢表雄酮 (DHEAS) 的血清浓度，该研究旨在确定 POF 患者和年龄匹配的正常月经对照受试者卵巢和肾上腺来源的雄激素浓度可能存在的差异，2 个人群的血清睾酮和 DHEAS 浓度没有显着差异。 POF患者组的血清雄烯二酮浓度（3,077.50 +/- 1,122.33 pmol/l）显着低于年龄匹配的正常对照受试者（4,167.70 +/- 1,381.09 pmol/l，p < 0.005），可能反映了卵巢雄烯二酮分泌的丧失和/或肾上腺类固醇生成能力的微妙缺陷。
Serum concentrations of androstenedione, testosterone and dehydroepiandrosterone sulfate (DHEAS) were measured in 29 patients with premature ovarian failure (POF) and an identical number of age-matched normal control subjects, The study was aimed at determining possible differences in androgen concentrations of ovarian and adrenal origin in POF patients and age-matched normal menstruating controls, Serum testosterone and DHEAS concentrations in the 2 populations were not significantly different. The serum androstenedione concentration in the POF patient group (3,077.50 +/- 1,122.33 pmol/l) was significantly lower than in age-matched normal control subjects (4,167.70 +/- 1,381.09 pmol/l, p < 0.005), possibly reflecting the loss of ovarian androstenedione secretion and/or a subtle defect in adrenal steroidogenic capacity.