SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases.
SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases.
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DOI：
10.2147/jir.s332705
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发表时间：
2021
影响因子：
4.5
通讯作者：
Alzahrani AS
中科院分区：
文献类型：
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作者：
Murugan AK;Alzahrani AS
2019年冠状病毒病（COVID-19）在大多数情况下是无症状的，但它在脆弱和老年人中是不可分割的和致命的。在此期间，超过400万人死于COVID-19，而它正在蔓延到地球仪的每一个地方。严重急性呼吸综合征-冠状病毒-2（SARS-CoV-2）通过利用ACE 2作为细胞进入的受体，诱导包括甲状腺在内的许多重要器官的各种功能障碍。新出现的报告清楚地表明SARS-CoV-2参与了各种甲状腺疾病。因此，本文旨在全面回顾SARS-CoV-2诱导的甲状腺疾病发病机制的所有最新进展。本文简要总结了SARS-CoV-2感染的机制、ACE 2受体在病毒侵入中的作用、SARS-CoV-2激活的宿主细胞分子信号传导、ACE 2在甲状腺中的表达、细胞因子风暴及其在甲状腺功能障碍和长期COVID与甲状腺和自身免疫的关系中的重要作用。此外，它广泛讨论了SARS-CoV-2在COVID-19期间和之后出现的各种甲状腺功能障碍中的潜在部分的快速发展的知识，包括亚急性甲状腺炎，Graves病，桥本甲状腺炎，甲状腺毒症，以及其他最近的进展，进一步辨别这种病毒在甲状腺功能障碍中的影响。揭示SARS-CoV-2触发的甲状腺功能障碍的病理生理学可能有助于在COVID-19期间和之后的情况下对这些患者进行相关的治疗选择和管理。
Coronavirus disease-2019 (COVID-19) is asymptomatic in most cases, but it is impartible and fatal in fragile and elderly people. Heretofore, more than four million people succumbed to COVID-19, while it spreads to every part of the globe. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) induces various dysfunctions in many vital organs including the thyroid by utilizing ACE2 as a receptor for cellular entry. Emerging reports clearly show the involvement of SARS-CoV-2 in diverse thyroid disorders. Thus, this review article aims to review comprehensively all the recent developments in SARS-CoV-2-induced pathogenesis of thyroid diseases. The review briefly summarizes the recent key findings on the mechanism of SARS-CoV-2 infection, the role of ACE2 receptor in viral entry, SARS-CoV-2-activated molecular signaling in host cells, ACE2 expression in the thyroid, cytokine storm, and its vital role in thyroid dysfunction and long-COVID in relation to thyroid and autoimmunity. Further, it extensively discusses rapidly evolving knowledge on the potential part of SARS-CoV-2 in emerging various thyroid dysfunctions during and post-COVID-19 conditions which include subacute thyroiditis, Graves' diseases, Hashimoto’s thyroiditis, thyrotoxicosis, and other recent advances in further discerning the implications of this virus within thyroid dysfunction. Unraveling the pathophysiology of SARS-CoV-2-triggered thyroid dysfunctions may aid pertinent therapeutic options and management of these patients in both during and post-COVID-19 scenarios.