Extensive extinction in multiple contexts eliminates the renewal of conditioned fear in rats
Extensive extinction in multiple contexts eliminates the renewal of conditioned fear in rats
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DOI：
10.1016/j.lmot.2008.10.002
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发表时间：
2009-05-01
影响因子：
1.4
通讯作者：
Novak, Cheryl
中科院分区：
文献类型：
--
作者：
Thomas, Brian L.;Vurbic, Drina;Novak, Cheryl
两项研究探讨了在多个背景下，而不是在一个单一的背景下，非强化刺激是否会减少大鼠条件性恐惧的更新（通过压杆的条件性抑制进行评估）。在实验1中。在单一环境中的六次消退期或三种不同环境中的每一种中的两次消退期期间进行36次非强化CS试验后测量更新。灭绝环境的数量对更新没有影响。在实验2中。在单一环境或三种不同环境中，在六次或二十四次消退会议期间，各组接受了36次或144次非强化CS试验。同样，当只提供36次试验时，更新不受灭绝环境数量的影响。然而，当使用144个试验时，当灭绝被分为3个环境时，更新被完全消除，但当会话发生在单一环境中时，更新并没有被削弱。研究结果表明，在基于胰岛素的治疗中使用多种治疗设置只有在每个治疗设置中提供足够数量的会话时才有可能减少复发。(c)2008年爱思唯尔公司All rights reserved.
Two studies examined whether nonreinforcement of a stimulus in multiple contexts, instead of a single context, would decrease renewal of conditioned fear in rats (as assessed by conditioned suppression of lever pressing). In Experiment 1. renewal was measured after 36 nonreinforced CS trials delivered during six extinction sessions in a single context or two extinction sessions in each of three different contexts. The number of extinction contexts did not have an effect on renewal. In Experiment 2. groups received either 36 or 144 nonreinforced CS trials during six or twenty-four extinction sessions in a single context or three different contexts. Again, renewal was not influenced by the number of extinction contexts when only 36 trials were given. However, when 144 trials were used, renewal was completely eliminated when extinction was divided between 3 contexts, but was not weakened when the sessions took place in a single context. The results suggest that the use of multiple treatment settings in exposure-based therapies is only likely to reduce relapse if a sufficient number of sessions are provided in each of the treatment settings. (c) 2008 Elsevier Inc. All rights reserved.