Central localization of plasticity involved in appetitive conditioning in Lymnaea
Central localization of plasticity involved in appetitive conditioning in Lymnaea
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DOI：
10.1101/lm.77004
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发表时间：
2004-11-01
影响因子：
2
通讯作者：
Benjamin, PR
中科院分区：
文献类型：
--
作者：
Straub, VA;Styles, BJ;Benjamin, PR
学习关联条件刺激 (CS) 和非条件刺激 (US) 会导致 CS 信息处理的变化。在这里，我们通过使用细胞外记录技术监测感觉处理途径两个阶段的神经元活动，直接解决了 Lymnaea 摄食行为的化学食欲调节是否涉及 CS 的外周和/或中枢处理的变化的问题。我们的数据表明，食欲调节不会显着影响连接嘴唇和触手化学感应结构与中枢神经系统（CNS）的传入神经的整体CS反应。相比之下，大脑神经节（代表化学感应信息的第一个中央处理阶段）的神经元输出在食欲调节后对 CS 的反应显着增强。这表明 Lymnaea 的化学食欲调节影响化学感应信息的中枢处理，但不影响外周处理。它还将 Lymnaea 的大脑神经节确定为神经元可塑性的重要部位，并构成神经元可塑性详细细胞研究的基础。
Learning to associate a conditioned (CS) and unconditioned stimulus (US) results in changes in the processing of CS information. Here, we address directly the question whether chemical appetitive conditioning of Lymnaea feeding behavior involves changes in the peripheral and/or central processing of the CS by using extracellular recording techniques to monitor neuronal activity at two stages of the sensory processing pathway. Our data show that appetitive conditioning does not affect significantly the overall CS response of afferent nerves connecting chemosensory structures in the lips and tentacles to the central nervous system (CNS). In contrast, neuronal output from the cerebral ganglia, which represent the first central processing stage for chemosensory information, is enhanced significantly in response to the CS after appetitive conditioning. This demonstrates that chemical appetitive conditioning in Lymnaea affects the central, but not the peripheral processing of chemosensory information. It also identifies the cerebral ganglia of Lymnaea as an important site for neuronal plasticity and forms the basis for detailed cellular Studies of neuronal plasticity.