Effect of 4-methyl-3-nitrobenzoic acid on non‑small cell lung cancer cell migration.
Effect of 4-methyl-3-nitrobenzoic acid on non‑small cell lung cancer cell migration.
复制标题
4-甲基-3-硝基苯甲酸对非小细胞肺癌细胞迁移的影响。
DOI：
10.3892/mmr.2011.527
复制
发表时间：
2011
影响因子：
3.4
通讯作者：
X. Hao
中科院分区：
文献类型：
--
作者：
Peng Chen;Xiaofang Zhang;Hua Guo;Ning Ma;Menghui Li;Zhe Liu;Ning Zhang;X. Hao
Metastasis is a major cause of mortality among lung cancer patients. In a previous high-throughput screening of 20,000 compounds to identify inhibitors of cancer cell migration, 4-methyl-3-nitrobenzoic acid was found to inhibit the migration of nine tumor cell lines. The present study used the human non-small cell lung cancer cell (NSCLC) treatment with 4-methyl-3-nitrobenzoic acid significantly inhibited epithelial growth factor (EGF)-induced chemotaxis and chemokinesis of cancer cells in NSCLC cells. The defect in chemotaxis is likely due to the impairment in EGF-induced cofilin phosphorylation and actin polymerization. Furthermore, EGF-induced cell adhesion, which is another key factor in cell migration, was also inhibited. Taken together, these results suggest that 4-methyl-3-nitrobenzoic acid is a potent inhibitor of cancer cell chemotaxis and may be developed into a novel antimetastasis drug.
DOI：
10.1016/j.bbamcr.2006.07.001
发表时间：
2007-05-01
影响因子：
5.1
作者：
Yamaguchi, Hideki;Condeelis, John
通讯作者：
Condeelis, John
影响因子：
20.3
作者：
Pluskota, E;Soloviev, DA;Plow, EF
通讯作者：
Plow, EF