Dynamics of sleep stage transitions in healthy humans and patients with chronic fatigue syndrome
Dynamics of sleep stage transitions in healthy humans and patients with chronic fatigue syndrome
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DOI：
10.1152/ajpregu.00925.2007
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发表时间：
2008-06-01
影响因子：
2.8
通讯作者：
Yamamoto, Yoshiharu
中科院分区：
文献类型：
--
作者：
Kishi, Akifumi;Struzik, Zbigniew R.;Yamamoto, Yoshiharu
生理和/或病理意义的动态睡眠阶段过渡尚未，到目前为止，进行了调查。我们报告了健康受试者和慢性疲劳综合征（CFS）患者睡眠阶段之间的详细持续时间和过渡统计数据;此外，我们还将我们的数据与先前发表的大鼠结果进行了比较。22名健康女性和22名女性CFS患者，其特征是抱怨睡眠不清醒，进行了一个晚上的多导睡眠记录。我们发现，深度睡眠（第三阶段和第四阶段）的持续时间遵循幂律概率分布函数;相反，第二阶段睡眠持续时间遵循拉伸指数和第一阶段，快速眼动睡眠持续时间遵循指数函数。这些阶段持续时间分布显示出随着睡眠深度的增加而逐渐偏离指数形式，朝向深度睡眠的幂律型分布，这表明更深睡眠阶段的调节越来越复杂。我们还发现人类中有大量的REM到非REM睡眠的过渡，而据报道，这种过渡在大鼠中几乎不存在。CFS患者中这种REM到非REM睡眠过渡的相对频率显著低于对照组，导致从REM和I期睡眠两者移动到清醒的相对过渡频率显著更高。这种转换模式的改变表明，在CFS患者中，正常的持续睡眠在浅睡眠或REM睡眠中被破坏。我们的结论是，睡眠阶段的动态转换分析是有用的阐明尚未确定的人类睡眠调节机制与病理生理学的影响。
Physiological and/or pathological implications of the dynamics of sleep stage transitions have not, to date, been investigated. We report detailed duration and transition statistics between sleep stages in healthy subjects and in others with chronic fatigue syndrome (CFS); in addition, we also compare our data with previously published results for rats. Twenty-two healthy females and 22 female patients with CFS, characterized by complaints of unrefreshing sleep, underwent one night of polysomnographic recording. We find that duration of deep sleep (stages III and IV) follows a power-law probability distribution function; in contrast, stage II sleep durations follow a stretched exponential and stage I, and REM sleep durations follow an exponential function. These stage duration distributions show a gradually increasing departure from the exponential form with increasing depth of sleep toward a power-law type distribution for deep sleep, suggesting increasing complexity of regulation of deeper sleep stages. We also find a substantial number of REM to non-REM sleep transitions in humans, while this transition is reported to be virtually nonexistent in rats. The relative frequency of this REM to non- REM sleep transition is significantly lower in CFS patients than in controls, resulting in a significantly greater relative transition frequency of moving from both REM and stage I sleep to awake. Such an alteration in the transition pattern suggests that the normal continuation of sleep in light or REM sleep is disrupted in CFS. We conclude that dynamic transition analysis of sleep stages is useful for elucidating yet-to-be-determined human sleep regulation mechanisms with pathophysiological implications.