Membrane curvature in cell biology: An integration of molecular mechanisms.
Membrane curvature in cell biology: An integration of molecular mechanisms.
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DOI：
10.1083/jcb.201604003
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发表时间：
2016-08-15
期刊：
影响因子：
--
通讯作者：
Gallop JL
中科院分区：
文献类型：
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作者：
Jarsch IK;Daste F;Gallop JL
弯曲的生物膜建立了细胞的复杂结构，并介导膜运输以控制通过亚细胞区室的通量。弯曲膜的常见分子机制在真核生物门的不同细胞生物学背景中是显而易见的。这些机制可以是膜双层（脂质或蛋白质组分）固有的，也可以是由外部因素（包括细胞骨架）引起的。在这里，我们回顾了在动物，真菌和植物中产生膜曲率的例子。我们展示了所涉及的分子机制以及它们如何合作，并继续强调曲率的背景，这是未来研究的令人兴奋的领域。从酵母和哺乳动物的细胞膜弯曲中得到的经验教训，为我们提供了一些暗示，我们希望看到植物和原生生物使用的分子机制。
Curving biological membranes establishes the complex architecture of the cell and mediates membrane traffic to control flux through subcellular compartments. Common molecular mechanisms for bending membranes are evident in different cell biological contexts across eukaryotic phyla. These mechanisms can be intrinsic to the membrane bilayer (either the lipid or protein components) or can be brought about by extrinsic factors, including the cytoskeleton. Here, we review examples of membrane curvature generation in animals, fungi, and plants. We showcase the molecular mechanisms involved and how they collaborate and go on to highlight contexts of curvature that are exciting areas of future research. Lessons from how membranes are bent in yeast and mammals give hints as to the molecular mechanisms we expect to see used by plants and protists.