Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project
Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project
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DOI：
10.1016/j.neurobiolaging.2012.01.005
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发表时间：
2012-11-01
影响因子：
4.2
通讯作者：
Nobili, Flavio
中科院分区：
文献类型：
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作者：
Morbelli, Silvia;Drzezga, Alex;Nobili, Flavio
我们探讨了静息状态的代谢连接在前驱阿尔茨海默氏病（pAD）患者和健康对照（CTR），通过逐体素区域间相关性分析18 F-氟脱氧葡萄糖（FDG）-正电子发射断层扫描（PET）的统计参数映射。对36例平均2年（pAD）和105 CTR后转化为阿尔茨海默病（AD）痴呆的遗忘型轻度认知障碍患者进行基线18 F-氟脱氧葡萄糖-正电子发射断层扫描。与CTR相比，pAD患者的低代谢区域显示出较少的代谢连接（分别与大颞叶和额叶区域的自相关性和相关性）。pAD患者即使在选定的非低代谢区（包括前额叶和背外侧前额叶皮层（DLFC））也显示出有限的相关性。相反，在CTR组中，前额叶皮层与楔前叶/后扣带回和额叶皮层之间的相关性突出，背外侧前额叶皮层与尾状核和顶叶皮层之间的相关性突出。pAD患者低代谢区和非低代谢区的代谢连接减少表明，代谢断开（反映早期神经联系不能）可能早于远程低代谢（突触变性的早期体征）。(c)2012 Elsevier Inc. All rights reserved.
We explored resting-state metabolic connectivity in prodromal Alzheimer's disease (pAD) patients and in healthy controls (CTR), through a voxel-wise interregional correlation analysis of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) by means of statistical parametric mapping. Baseline 18F-fluorodeoxyglucose-positron emission tomography of 36 patients with amnestic mild cognitive impairment who converted to Alzheimer's disease (AD) dementia after an average time of 2 years (pAD) and of 105 CTR were processed. The area of hypometabolism in pAD showed less metabolic connectivity in patients than in CTR (autocorrelation and correlation with large temporal and frontal areas, respectively). pAD patients showed limited correlation even in selected nonhypometabolic areas, including the hippocampi and the dorsolateral prefrontal cortex (DLFC). On the contrary, in CTR group correlation was highlighted between hippocampi and precuneus/posterior cingulate and frontal cortex, and between dorsolateral prefrontal cortex and caudate nuclei and parietal cortex. The reduced metabolic connections both in hypometabolic and nonhypometabolic areas in pAD patients suggest that metabolic disconnection (reflecting early diaschisis) may antedate remote hypometabolism (early sign of synaptic degeneration). (c) 2012 Elsevier Inc. All rights reserved.