Circadian variation in renal blood flow and kidney function in healthy volunteers monitored with noninvasive magnetic resonance imaging
Circadian variation in renal blood flow and kidney function in healthy volunteers monitored with noninvasive magnetic resonance imaging
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DOI：
10.1152/ajprenal.00311.2020
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发表时间：
2020-12-01
影响因子：
4.2
通讯作者：
Liss，Per
中科院分区：
文献类型：
--
作者：
Eckerbom，Per;Hansell，Peter;Liss，Per
肾功能的昼夜节律调节涉及维持全身内稳态，并且功能失调的昼夜节律可能涉及疾病的发展。磁共振成像（MRI）可无创地提供可靠且可重复的肾功能重复评估，而无造影剂和电离辐射相关不良事件的风险。本研究的目的是估计在健康人受试者的肾功能与MRI的昼夜变化，并与电解质和肾功能的标志物的尿液排泄的结果。采用相位对比成像、动脉自旋标记和血氧水平依赖性横向弛豫率（R2 *）标测评估8名女性和8名男性健康志愿者在24小时内每4小时的总肾血流量和区域灌注以及肾内氧合。与MRI扫描平行，定量标准尿液和血浆参数。在24小时内发现肾血流量的昼夜变化，从中午到午夜流量增加，夜间流量减少。与此相反，没有昼夜变化的肾内氧合检测。电解质、代谢活性颗粒、肌酐和尿素的尿液排泄均显示出昼夜节律变化，在下午和晚上达到峰值。总之，总肾血流量和肾功能，从电解质和废物的排泄估计，显示深刻的昼夜变化，而肾内氧合显示明显较少的昼夜变化。
Circadian regulation of kidney function is involved in maintaining whole body homeostasis, and dysfunctional circadian rhythm can potentially be involved in disease development. Magnetic resonance imaging (MRI) provides reliable and reproducible repetitive estimates of kidney function noninvasively without the risk of adverse events associated with contrast agents and ionizing radiation. The purpose of this study was to estimate circadian variations in kidney function in healthy human subjects with MRI and to relate the findings to urinary excretions of electrolytes and markers of kidney function. Phase-contrast imaging, arterial spin labeling, and blood oxygen level-dependent transverse relaxation rate (R 2*) mapping were used to assess total renal blood flow and regional perfusion as well as intrarenal oxygenation in eight female and eight male healthy volunteers every fourth hour during a 24-h period. Parallel with MRI scans, standard urinary and plasma parameters were quantified. Significant circadian variations of total renal blood flow were found over 24 h, with increasing flow from noon to midnight and decreasing flow during the night. In contrast, no circadian variation in intrarenal oxygenation was detected. Urinary excretions of electrolytes, osmotically active particles, creatinine, and urea all displayed circadian variations, peaking during the afternoon and evening hours. In conclusion, total renal blood flow and kidney function, as estimated from excretion of electrolytes and waste products, display profound circadian variations, whereas intrarenal oxygenation displays significantly less circadian variation.