Impairments of behavior, information flow between thalamus and cortex, and prefrontal cortical synaptic plasticity in an animal model of depression
Impairments of behavior, information flow between thalamus and cortex, and prefrontal cortical synaptic plasticity in an animal model of depression
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DOI：
10.1016/j.brainresbull.2011.03.002
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发表时间：
2011-05-30
影响因子：
3.8
通讯作者：
Yang, Zhuo
中科院分区：
文献类型：
--
作者：
Quan, Meina;Zheng, Chenguang;Yang, Zhuo
越来越多的证据表明，压力与抑郁症的病理生理有关。本研究旨在测试应激抑郁症模型的行为和电生理变化。将大鼠随机分为对照组和应激组。应激组大鼠采用慢性不可预知应激联合隔离饲养3周。在造模期间测定大鼠体重和蔗糖消耗量。行为学采用Morris水迷宫测量。在行为测试后记录丘脑和前额叶皮层的脑电图（EEG），随后记录同一丘脑皮层通路的长期增强（LTP）。结果表明，应激组大鼠体重和蔗糖摄取量明显低于对照组。应激组水迷宫逆转训练阶段的逃避潜伏期显著延长，逆转探针试验的跨台次数显著减少。脑电图显示，应激组丘脑对前额叶皮层的驱动程度减小。LTP试验显示，应激组突触后电位幅值低于对照组。综上所述，慢性应激可引起大鼠一定的行为改变，其机制可能是丘脑皮质通路脑电图和前额皮质突触可塑性受损。(C) 2011爱思唯尔公司版权所有。
Growing evidence suggests the involvement of stress in the pathophysiology of depression. This study was designed to test behavioral and electrophysiological changes in a stressed model of depression. Rats were randomly divided into control and stressed groups. Chronic unpredictable stress combined with isolation rearing was applied in rats of stressed group for three weeks. Weight and sucrose consumption were measured during the model establishing period. Behavior was measured by Morris water maze. Electroencephalography (EEG) of thalamus and prefrontal cortex was recorded after behavioral tests, followed by recording long-term potentiation (LTP) of the same thalamocortical pathway. Results showed that rats' weight and sucrose intake were significantly lower in stressed group than those in control group. In stressed group, escape latency of reversal training stage in water maze test was significantly prolonged, and platform crossings of reversal probe trials were significantly decreased. EEG test showed that the extent of thalamus driving prefrontal cortex was decreased in stressed group. LTP test showed lower postsynaptic potential amplitude in stressed group as compared to that in control group. In conclusion, chronic stress could cause certain behavioral changes in rats, with possible mechanism of impairing EEG of certain thalamocortical pathway and prefrontal cortical synaptic plasticity. (C) 2011 Elsevier Inc. All rights reserved.