Caspase activation and mitochondrial cytochrome c release during hypoxia-mediated apoptosis of adult ventricular myocytes
Caspase activation and mitochondrial cytochrome c release during hypoxia-mediated apoptosis of adult ventricular myocytes
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DOI：
10.1006/jmcc.1999.1057
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发表时间：
2000-01-01
影响因子：
5
通讯作者：
Kirshenbaum, LA
中科院分区：
文献类型：
--
作者：
de Moissac, D;Gurevich, RM;Kirshenbaum, LA
长时间的缺氧会导致心肌细胞死亡和心功能不全。防止心肌细胞死亡的能力对于维持损伤后的心功能具有重要的治疗价值，尽管caspase被认为在细胞凋亡中发挥关键作用，但它们在缺氧损伤中的作用尚未正式确定。在本报告中，我们发现成人心肌细胞在低氧1h后，其数量增加了三倍(P
Oxygen deprivation for prolonged periods leads to cardiac cell death and ventricular dysfunction. The ability to prevent myocardial cell death would be of significant therapeutic value in maintaining cardiac function after injury, While caspases have been suggested to play a critical role in apoptosis, their involvement during hypoxic injury has not been formally determined. In this report, we show that adult ventricular myocytes subjected to hypoxia for 1 h undergo a three-fold increase (P