IMMUNOGLOBULIN-A DEFICIENCY - GENETIC-STUDIES

IMMUNOGLOBULIN-A DEFICIENCY - GENETIC-STUDIES
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DOI:
10.1111/j.1399-0039.1982.tb01437.x
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发表时间:
1982-01-01
期刊:
影响因子:
--
通讯作者:
SCHROEDER, ML
SCHROEDER, ML
中科院分区:
医学4区
文献类型:
--
作者:
OEN, K;PETTY, RE;SCHROEDER, ML

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72,296名献血者中有155人IgA缺乏(< 0.01 mg/ml)。对60个献血者家庭的研究显示,12个家庭的其他成员也缺乏IgA。没有发现IgA缺乏遗传的一致模式。62名无亲缘关系的IgA缺陷献血者HLA分型显示HLA- b8患病率显著升高(P < 0.005)。
IgA deficiency (< 0.01 mg/ml) was demonstrated in 155 of 72,296 blood donors. Studies of families of 60 donors revealed IgA deficiency in other members of 12 families. No consistent pattern of inheritance of IgA deficiency was found. HLA typing of 62 unrelated IgA deficient blood donors showed a significant increase in the prevalence of HLA-B8 (P < 0.005).