The effect of vitamin D on bone and osteoporosis
The effect of vitamin D on bone and osteoporosis
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DOI：
10.1016/j.beem.2011.05.002
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发表时间：
2011-08-01
影响因子：
7.4
通讯作者：
van Schoor, Natasja M.
中科院分区：
文献类型：
--
作者：
Lips, Paul;van Schoor, Natasja M.
活性维生素 D 代谢物 1,25(OH)2D 的主要作用是刺激肠道对钙的吸收。维生素D缺乏的后果是继发性甲状旁腺功能亢进和骨质流失，导致骨质疏松和骨折，矿化缺陷，长期可能导致骨软化，以及肌肉无力，导致跌倒和骨折。维生素 D 状态与骨矿物质密度和骨转换有关。补充维生素 D 可能会降低骨转换并增加骨矿物质密度。几项使用维生素 D 和钙的随机安慰剂对照试验显示，骨折发生率显着降低。然而，每年一次极高剂量的维生素 D 可能会产生不利影响。当骨质疏松症患者接受双磷酸盐治疗时，他们应该补充维生素 D 和钙，除非患者维生素 D 充足。本评论详细讨论了这些主题。最后，讨论了知识差距和研究议程。 (C) 2011 Elsevier Ltd. 保留所有权利。
The main effect of the active vitamin D metabolite 1,25(OH)2D is to stimulate the absorption of calcium from the gut. The consequences of vitamin D deficiency are secondary hyperparathyroidism and bone loss, leading to osteoporosis and fractures, mineralization defects, which may lead to osteomalacia in the long term, and muscle weakness, causing falls and fractures. Vitamin D status is related to bone mineral density and bone turnover. Vitamin D supplementation may decrease bone turnover and increase bone mineral density. Several randomized placebo-controlled trials with vitamin D and calcium showed a significant decrease in fracture incidence. However, very high doses of vitamin D once per year may have adverse effects. When patients with osteoporosis are treated with a bisphosphonate, they should receive a vitamin D and calcium supplement unless the patient is vitamin D replete. These subjects are discussed in detail in this review. Finally, the knowledge gaps and research agenda are discussed. (C) 2011 Elsevier Ltd. All rights reserved.