Anti-obesity effects of DHA and EPA in high fat-induced insulin resistant mice
Anti-obesity effects of DHA and EPA in high fat-induced insulin resistant mice
复制标题
DHA 和 EPA 对高脂诱导的胰岛素抵抗小鼠的抗肥胖作用
DOI：
10.1039/d0fo02448a
复制
发表时间：
2021
期刊：
影响因子：
6.1
通讯作者：
Limei Mao
中科院分区：
文献类型：
--
作者：
Wenting Wei;Manjiang Hu;Jie Huang;Siyan Yu;Xudong Li;Yanhui Li;Limei Mao
二十二碳六烯酸（DHA，22：6）和二十碳五烯酸（EPA，20：5）已被报道改善代谢紊乱，但它们在胰岛素抵抗（IR）下的抗肥胖的不同作用仍然不清楚。我们用添加1%、2%、4%（w/w）DHA或EPA的高脂饲料喂养IR小鼠12周。评估体重、摄食量、白色脂肪组织（WAT）、肝脏和血脂的变化。通过检测WAT中GPR 120、PPARγ的表达，探讨DHA和EPA抗IR小鼠肥胖的相关分子机制。1%DHA和1%EPA通过下调GPR 120抑制脂肪生成; 4%DHA通过上调PPARγ抑制WAT的布朗宁，改善IR和炎症浸润; 4%EPA通过不依赖于PPARγ和GPR 120信号的机制发挥其抗肥胖作用。
Docosahexaenoic acid (DHA, 22:6) and eicosapentaenoic acid (EPA, 20:5) have been reported to improve.metabolic disorders, but their differential effects on anti-obesity under insulin resistance (IR) are still.unclear. We fed IR mice with high-fat diet with added 1%, 2%, 4% (w/w) DHA or EPA for 12 weeks..Changes in weight, food intake, white adipose tissue (WAT), liver and blood lipids were assessed. GPR120.and PPARγ of WAT were evaluated to explore the related molecular mechanisms of DHA and EPA for anti-.obesity in IR mice. 1%DHA and 1%EPA inhibit adipogenesis by down-regulating GPR120; 4%DHA stimu-.lates browning of WAT and improves IR and inflammatory infiltration by up-regulating PPARγ; 4%EPA.exerts its anti-obesity effect by mechanisms independent of PPARγ and GPR120 signaling.