On cytoadhesion of Plasmodium vivax: raison d'être?
On cytoadhesion of Plasmodium vivax: raison d'être?
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DOI：
10.1590/s0074-02762011000900010
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发表时间：
2011-08-01
期刊：
影响因子：
--
通讯作者：
Portillo, Hernando del
中科院分区：
文献类型：
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作者：
Costa, Fabio TM;Lopes, Stefanie CP;Portillo, Hernando del
人们普遍认为，间日疟原虫是分布最广的人类疟疾寄生虫，引起轻度疾病，而且该物种不会隔离在内脏的深层毛细血管中。然而，最近的证据表明，有严重的疾病，有时导致死亡，完全与间日疟原虫和间日疟原虫感染的网织红细胞能够在体外细胞粘附到不同的内皮细胞和胎盘冷冻切片。在这里，我们回顾了间日疟原虫细胞粘附的稀缺和初步数据，加强了这种现象在这个物种中的重要性，并强调了它为我们理解这种被忽视的人类疟疾寄生虫的病理学打开的途径。
It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.