Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer
Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer
复制标题
DOI：
10.1093/jnci/88.5.270
复制
发表时间：
1996-03-06
期刊：
影响因子：
--
通讯作者：
Stovall, MA
中科院分区：
文献类型：
--
作者：
Hawkins, MM;Wilson, LMK;Stovall, MA
背景：儿童时期患癌症的个体患骨癌的风险高于任何其他类型的第二原发性癌症。目的：我们使用英国儿童肿瘤国家登记处的人口为基础，在队列研究和病例对照研究中调查了儿童癌症后第二原发性骨癌的发病率和病因。方法：1940年至1983年在英国诊断的13175例3年儿童癌症幸存者的队列研究显示，55例随后的骨癌。一项大规模巢式病例对照研究包括59例发生第二原发性骨癌的病例受试者，选择220例对照受试者，并在性别、首次癌症类型、首次癌症年龄以及首次癌症诊断与随后骨癌之间的间隔方面进行匹配。结果的措施是骨癌的发病率后，儿童癌症，在第二骨癌的情况下，受试者在相应的解剖部位在匹配的对照受试者，和累积剂量的烷化剂和长春花生物碱的情况下和对照受试者的网站收到的辐射。结果如下：除了遗传性视网膜母细胞瘤（7.2%）、尤文氏肉瘤（5.4%）和其他恶性骨肿瘤（2.4%）外，3年生存者在20年内患骨癌的百分比不超过0.9%。随着骨累积辐射剂量的增加，患骨癌的危险性显著增加（P
Background: Individuals who had cancer in childhood are at higher risk of developing bone cancer than any other type of second primary cancer. Purpose: Using the population-based National Registry of Childhood Tumours in Britain, we investigated the incidence and etiology of second primary bone cancer after childhood cancer in a cohort study and in a case-control study. Methods: A cohort study of 13 175 3-year survivors of childhood cancer diagnosed in Britain between 1940 and 1983 revealed 55 subsequent bone cancers. A largely nested case-control study comprised 59 case subjects developing second primary bone cancer, and 220 control subjects were selected and matched for sex, type of first cancer, age at first cancer, and interval between diagnosis of first cancer and subsequent bone cancer. Outcome measures were the incidence of bone cancer after childhood cancer, the cumulative dose of radiation received at the site of the second bone cancer in the case subject and at the corresponding anatomic site in the matched control subjects, and the cumulative dose of alkylating agents and vinca alkaloids received by case and control subjects. Results: The percentage of 3-year survivors developing bone cancer within 20 years did not exceed 0.9%, except following heritable retinoblastoma (7.2%), Ewing's sarcoma (5.4%), and other malignant bone tumors (2.4%). The risk of bone cancer increased substantially with increased cumulative dose of radiation to the bone (P