The association of dietary fat and plant foods with endometrial cancer (United States)
The association of dietary fat and plant foods with endometrial cancer (United States)
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DOI：
10.1023/a:1011292003586
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发表时间：
2001-10-01
影响因子：
2.3
通讯作者：
White, E
中科院分区：
文献类型：
--
作者：
Littman, AJ;Beresford, SAA;White, E
目的：在一项基于人群的病例对照研究中，探讨膳食脂肪和选定的植物性食物与子宫内膜癌的关系。1985年至1991年期间诊断的679例子宫内膜癌病例，和944名基于人群的对照者完成了一份98项半定量食物频率问卷和一份详细的-个人访谈，收集有关子宫内膜癌危险因素的信息。Logistic回归分析用于估计子宫内膜癌的优势比（OR）及其95%可信区间（CI），校正了年龄、地区、能量摄入、激素使用、吸烟以及不同模型中的体重指数（BMI：kg/m2）。最低：OR = 1.8，95% CI 1.3-2.6），饱和脂肪和单不饱和脂肪是风险的主要贡献者。在循环雌激素水平较高的群体中（即BMI较高的女性、使用非对抗性雌激素的女性、不吸烟者和初潮年龄较小的女性），膳食脂肪与子宫内膜癌之间的关联更强。水果或蔬菜的消费量与子宫内膜癌风险呈负相关（最高五分位数，参见最低：OR = 0.65，95%CI 0.46-0.93和OR = 0.61，95%CI 0.43-0.88）。进一步调整BMI导致很少或没有衰减的OR和相关的CIs.Conclusions：这些结果提供了支持的理论，即低脂肪，高水果和高蔬菜饮食可能会降低子宫内膜癌的风险，这些饮食因素可能会独立的BMI的影响。
Objectives: To examine the associations of dietary fat and selected plant foods with endometrial cancer in a population-based case-control study.Methods: Six hundred and seventy-nine incident cases of endometrial cancer diagnosed between 1985 and 1991, and 944 population-based controls completed a 98-item semi-quantitative food-frequency questionnaire and a detailed in-person interview which collected information on endometrial cancer risk factors. Logistic regression was used to estimate odds ratios (OR) and their 95% confidence intervals (CI) of endometrial cancer, adjusted for age, county, energy intake, hormone use, smoking and, in separate models, for body mass index (BMI: kg/m(2)).Results: Percent energy from fat was associated with an increased risk of endometrial cancer (highest quintile cf. lowest: OR = 1.8, 95% CI 1.3-2.6), with saturated and monounsaturated fats being the main contributors of risk. There was a stronger association between dietary fat and endometrial cancer among groups with higher circulating estrogen levels (i.e. women with higher BMI, users of unopposed estrogens, non-smokers, and younger age at menarche). Consumption of fruits or vegetables was inversely associated with endometrial cancer risk (highest quintile cf. lowest: OR = 0.65, 95% CI 0.46-0.93 and OR = 0.61, 95% CI 0.43-0.88, respectively). Further adjustment for BMI resulted in little or no attenuation of the ORs and associated CIs.Conclusions: These results provide support for the theory that a low-fat, high-fruit and high-vegetable diet may reduce the risk of endometrial cancer, and that these dietary factors may act independently of the effect of BMI.