Antiretroviral therapy is associated with sexual dysfunction and with increased serum oestradiol levels in men
Antiretroviral therapy is associated with sexual dysfunction and with increased serum oestradiol levels in men
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DOI：
10.1258/095646204773557749
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发表时间：
2004-04-01
影响因子：
1.4
通讯作者：
Scullard, G
中科院分区：
文献类型：
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作者：
Lamba, H;Goldmeier, D;Scullard, G
我们的目的是确定高效抗逆转录病毒治疗（HAART），血清总雌二醇和HIV感染的男性性功能障碍之间的关系。在一组HIV阴性（或未知状态）男同性恋/双性恋男性（MSM）和一组HIV感染男性中前瞻性地记录了性困难。艾滋病毒感染者被分为接受和不接受HAART治疗的人，并按性别划分。如可能，评价血清总雌二醇和睾酮水平。分析了100例HIV阴性MSM和73例HIV感染者（88% MSM）。在对照组中，性欲低下和勃起功能障碍（艾德）的发生率分别为2%和10%。相比之下，在未接受HAART的HIV感染的MSM中，这两个问题的患病率为26%。在那些接受HAART治疗的MSM中，48%的人注意到性欲下降，25%的人注意到艾德。在服用HAART的男性组中，平均雌二醇水平为228 pmol/L，明显高于正常范围。低性欲和艾德更常见于HIV感染的男性，与阴性或未知状态的男同性恋者相比。HAART与性欲缺乏和血清雌二醇水平升高的患病率较高相关。
Our objective was to determine the relationship between highly active antiretroviral therapy (HAART), serum total oestradiol and sexual dysfunction in HIV-infected men. Sexual difficulties were recorded prospectively in a cohort of HIV-negative (or unknown status) gay/bisexual men (MSM) and a cohort of HIV-infected men. The HIV-infected men were divided into those on and not on HAART and by sexuality. Serum total oestradiol and testosterone levels were evaluated where possible. One hundred HIV-negative MSM and 73 HIV-infected men (88% MSM) were analysed. Low libido and erectile dysfunction (ED) were reported in the control group in 2% and 10% respectively. This compared to a prevalence of 26% for both problems in HIV-infected MSM not taking HAART. In those MSM on HAART reduced libido was noted in 48% and ED in 25%. In the group of men taking HAART the mean oestradiol level was 228 pmol/L and was significantly above normal limits. Low libido and ED are more commonly reported in HIV-infected men compared to gay men of negative or unknown status. HAART is associated with a higher prevalence of lack of sexual desire and raised serum oestradiol levels.