Can pupil size and pupil responses during visual scanning contribute to the diagnosis of autism spectrum disorder in children?
Can pupil size and pupil responses during visual scanning contribute to the diagnosis of autism spectrum disorder in children?
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DOI：
10.1016/j.jpsychires.2011.01.008
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发表时间：
2011-08-01
影响因子：
4.8
通讯作者：
Bonnet-Brilhault, Frederique
中科院分区：
文献类型：
--
作者：
Martineau, Joelle;Hernandez, Nadia;Bonnet-Brilhault, Frederique
本研究的目的是确定使用眼动追踪技术进行视觉扫描时的基线瞳孔大小和瞳孔反应是否可以将自闭症谱系障碍 (ASD) 儿童与心理年龄匹配和时间年龄匹配的对照儿童区分开来。为此，我们使用由静态彩色照片组成的刺激，这些照片集中呈现在刺激监视器上参与者的中线处。每个孩子都会看到一系列中性面孔、虚拟面孔（化身）和不同的物体，并用黑色幻灯片隔开。我们记录了三类刺激中以及暴露于黑色幻灯片期间的平均瞳孔大小和瞳孔大小随时间的变化。 57 名儿童参与了研究（19 名自闭症谱系障碍儿童，平均年龄 118 个月；19 名心理年龄匹配的对照组，平均年龄 87 个月；19 名实际年龄匹配的对照组，平均年龄 118 个月）。我们比较了三个诊断组之间视觉扫描期间的基线瞳孔大小和瞳孔反应。在幻灯片演示过程中，ASD 组的平均瞳孔大小明显小于 MA 匹配组和 CA 匹配组。在展示黑色幻灯片和带有视觉刺激的幻灯片期间对瞳孔大小的判别分析成功预测了 72% 的参与者的群体成员身份。 ASD 组中 89% 的参与者、MA 匹配组中的 63% 和 CA 匹配组中的 63% 的参与者的组成员身份被正确分类。这些潜在的生物标志物可能有助于我们了解自闭症患者大脑神经发育的差异，并且可以作为自闭症谱系障碍的指标。 (C) 2011 Elsevier Ltd. 保留所有权利。
The purpose of this study was to determine whether baseline pupil size and pupil responses during visual scanning with eye-tracking technology could discriminate children with Autism Spectrum Disorder (ASD) from mental age-matched and chronological age-matched controls. To this end, we used stimuli consisting in still color photographs presented centrally to the participant's midline on a stimulus monitor. Each child was presented with a series of neutral faces, virtual faces (avatars) and different objects, separated by black slides. We recorded the mean pupil size and pupil size changes over time in each of the three categories of stimuli and during exposure to the black slides. Fifty-seven children participated in study (19 ASD, mean age 118 months: 19 mental age-matched controls, mean age 87 months; and 19 chronological age-matched controls, mean age 118 months). We compared the baseline pupil size and pupil responses during visual scanning among the three diagnostic groups. During the presentation of slides, the mean pupil size in the ASD group was clearly smaller than in the MA-matched and CA-matched groups. Discriminate analysis of pupil size during the presentation of black slides and slides with visual stimuli successfully predicted group membership in 72% of the participants. Group membership was correctly classified in 89% of the participants in the ASD group, in 63% in the MA-matched group and in 63% in the CA-matched group. These potential biomarkers may contribute to our understanding of the differences in neurological development in the brain in autism and could prove useful as indicators of ASD. (C) 2011 Elsevier Ltd. All rights reserved.