Phylogenetic mixtures on a single tree can mimic a tree of another topology
Phylogenetic mixtures on a single tree can mimic a tree of another topology
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DOI：
10.1080/10635150701627304
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发表时间：
2007-10-01
影响因子：
6.5
通讯作者：
Steel, Mike
中科院分区：
文献类型：
--
作者：
Matsen, Frederick A.;Steel, Mike
系统发育混合物模拟了数据中常见的不均匀分子进化。由混合模型生成基础数据的系统发育重建方法的性能最近引发了相当多的争论。许多争议源于对给定树拓扑的混合模型数据的模拟，其中重建算法输出不同拓扑的树；这些发现被用来表明特定树木重建方法的缺点。这样做的基本假设是，在给定足够的数据和“正确”方法的情况下，一种拓扑上的混合模型数据可以与另一种拓扑的非混合树上演化的数据区分开来。在这里我们证明这个假设可能是错误的。对于生物学家来说，我们的结果意味着，例如，系统发育树仅在分支长度方面不同的两个基因的组合数据可以完美地拟合不同拓扑的树。 [混合模型；模型可识别性；系统发生学；序列进化。]
Phylogenetic mixtures model the inhomogeneous molecular evolution commonly observed in data. The performance of phylogenetic reconstruction methods where the underlying data are generated by a mixture model has stimulated considerable recent debate. Much of the controversy stems from simulations of mixture model data on a given tree topology for which reconstruction algorithms output a tree of a different topology; these findings were held up to show the shortcomings of particular tree reconstruction methods. In so doing, the underlying assumption was that mixture model data on one topology can be distinguished from data evolved on an unmixed tree of another topology given enough data and the "correct" method. Here we show that this assumption can be false. For biologists, our results imply that, for example, the combined data from two genes whose phylogenetic trees differ only in terms of branch lengths can perfectly fit a tree of a different topology. [Mixture model; model identifiability; phylogenctics; sequence evolution.]