Decrease in generation of reactive oxygen species by neutrophils from patients with infectious mononucleosis: role of suppressor T lymphocytes.
Decrease in generation of reactive oxygen species by neutrophils from patients with infectious mononucleosis: role of suppressor T lymphocytes.
复制标题
传染性单核细胞增多症患者中性粒细胞产生的活性氧减少：抑制性 T 淋巴细胞的作用。
DOI：
10.1182/blood.v64.5.994.bloodjournal645994
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发表时间：
1984
期刊：
影响因子：
20.3
通讯作者：
K. Somiya
中科院分区：
文献类型：
--
作者：
Y. Niwa;T. Sakane;Y. Miyachi;T. Kanoh;K. Somiya
我们评估了活性氧（ROS：O2-，H2 O2，OH）的产生。化学发光）。与两个对照组相比，传染性单核细胞增多症患者的中性粒细胞显示所有活性氧的产生显著减少;这种异常在疾病发作后持续4至8周。来自这些患者的单核细胞产生正常水平的ROS。与来自传染性单核细胞增多症患者的T淋巴细胞孵育的正常中性粒细胞产生的每种ROS显著低于与来自任一对照组的T细胞孵育的正常中性粒细胞。T细胞介导的ROS生成抑制需要来自传染性单核细胞增多症患者的OKT 4+细胞和来自患者或正常人的OKT 8+细胞。我们的结论是，中性粒细胞中的反应氧的产生抑制传染性单核细胞增多症患者，至少部分，通过相互作用的T淋巴细胞亚群。
We assessed the generation of reactive oxygen species (ROS: O2-, H2O2, OH . , chemiluminescence) by neutrophils and monocytes from six patients with infectious mononucleosis, ten patients with other viral diseases, and ten normal controls. Neutrophils from infectious mononucleosis patients showed markedly decreased generation of all reactive oxygen species, compared with the two control groups; this abnormality persisted for four to eight weeks after disease onset. Monocytes from these patients generated normal levels of ROS. Normal neutrophils incubated with T lymphocytes from infectious mononucleosis patients generated significantly less of each ROS than did those incubated with T cells from either control group. T cell-mediated suppression of ROS generation required both OKT4+ cells from infectious mononucleosis patients and OKT8+ cells from either patients or normals. We conclude that the generation of reaction oxygen species in neutrophils is suppressed in patients with infectious mononucleosis, at least in part, by interacting subsets of T lymphocytes.