Fibroblast imaging of hepatic carcinoma with68Ga-FAPI-04 PET/CT: a pilot study in patients with suspected hepatic nodules
Fibroblast imaging of hepatic carcinoma with68Ga-FAPI-04 PET/CT: a pilot study in patients with suspected hepatic nodules
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(68)Ga-FAPI-04 PET/CT 肝癌成纤维细胞成像：疑似肝结节患者的初步研究
DOI：
10.1007/s00259-020-04882-z
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发表时间：
2020-05-29
影响因子：
9.1
通讯作者：
Li, Xiang
中科院分区：
文献类型：
--
作者：
Shi, Ximin;Xing, Haiqun;Li, Xiang
目的GA-68-FAPI-04是一种快速进化的PET示踪剂，用于多种癌症的全身成像。我们的目的是评价(68)Ga-FAPI-04对可疑癌症患者的肝脏结节的诊断性能。方法对25例可疑肝脏恶性肿瘤的患者行(68)Ga-FAPI-04PET检查。测量所有病灶和正常肝组织的最大摄取值和平均摄取值(SUVmax、SUVean)。将病灶的SUV(Max)除以非肿瘤性肝组织的SUV(平均值)，计算靶底比(TBR)。病灶摄取值与免疫组织化学(IHC)测定的体外肝脏FAP表达相关。结果总共有17名接受手术或活检的患者进入最终分析。16例患者共检出肝内恶性病变28个，平均SUV(Max)为8.36+/-4.21(2.21~15.86)，平均TBR为13.15+/-9.48(2.79~38.12)。1例良性病变的肝脏摄取可忽略不计(SUVmax=0.47)，而75%的肝内肝细胞癌(肝癌)病变(n=6)FAP表达显著，12.5%(n=1)的病变间质细胞呈中度表达，1例可忽略表达。结论GA-68-FAPI-04对肝脏恶性肿瘤的诊断具有较高的敏感性，尤其是在FAP表达明显升高的低分化型中。
Purpose Ga-68-FAPI-04 is a rapidly evolving PET tracer for whole-body imaging in a variety of cancers. We aimed to evaluate the diagnostic performance of(68)Ga-FAPI-04 for detecting and characterizing hepatic nodules in patients with suspected carcinoma. Methods Twenty-five patients showing suspicious hepatic lesions for malignancy underwent(68)Ga-FAPI-04 PET. The maximum and mean standardised uptake values (SUVmax, SUVmean) were measured for all detected lesions and normal hepatic tissues, respectively. The target-to-background ratio (TBR) was calculated by dividing the lesion SUV(max)with the SUV(mean)of non-tumour liver tissue. Lesion uptake value was correlated with the in vitro hepatic FAP expression determined by immunohistochemistry (IHC). Results In total, 17 patients who underwent surgery or biopsy were recruited for the final analysis. A total of 28 intrahepatic malignant lesions were detected in 16 patients; the mean SUV(max)was 8.36 +/- 4.21 (range 2.21 to 15.86), and mean TBR was 13.15 +/- 9.48 (range 2.79 to 38.12) in all detected lesions (n = 28). One benign patient showed negligible hepatic uptake (SUVmax = 0.47), whereas 75% of the primary intrahepatic hepatocellular carcinoma (HCC) lesions (n = 6) showed prominent FAP expression, 12.5% of the lesions (n = 1) showed moderate expression in stromal cells, and one showed negligible expression. Conclusions Ga-68-FAPI-04 showed high sensitivity in detecting hepatic malignancies, particularly in poorly differentiated forms with concordantly elevated FAP expression.